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- [31] Increased STAT-3 Activity in Smooth Muscle Cells of Stricturing Crohn's Disease Upregulates MicroRNA-21 and Leads to Dysregulation of Inhibitory Smad7 Signaling, Increased Expression of TGF-β1 Regulated Profibrotic Genes and Can Be Reserved by the STAT-3 Inhibitor, Stattic GASTROENTEROLOGY, 2012, 142 (05) : S872 - S872