Overexpression of Smad7 prevents TGF-β and activin signaling and function in erythroleukemic cells but increases endomitosis during megakaryocytic differentiation.

被引：0
|
作者：
Akel, SM [1 ]
Bertolette, DC [1 ]
Ruscetti, FW [1 ]
机构：
[1] NCI, Frederick Canc Res & Dev Ctr, Basic Res Lab, CCR, Frederick, MD 21701 USA
来源：
BLOOD | 2002年 / 100卷 / 11期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
2040
引用
收藏
页码：522A / 522A
页数：1
相关论文
共 31 条
  • [1] Blockade of the effects of TGF-β1 on mesangial cells by overexpression of Smad7
    Chen, RH
    Huang, CC
    Morinelli, TA
    Trojanowska, M
    Paul, RV
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2002, 13 (04):
  • [2] Overexpression of smad7 inhibits the TGF-β/Smad signaling pathway and EMT in NPHP1-defective MDCK cells
    Wu, Xiaohong
    Wang, Haiyan
    Chen, Huamu
    Lin, Hongrong
    Li, Min
    Yue, Zhihui
    Sun, Liangzhong
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021, 582 : 57 - 63
  • [3] Smad7 interrupts TGF-β signaling in intestinal macrophages and promotes inflammatory activation of these cells during necrotizing enterocolitis
    MohanKumar, Krishnan
    Namachivayam, Kopperuncholan
    Chapalamadugu, Kalyan C.
    Garzon, Steven A.
    Premkumar, Muralidhar H.
    Tipparaju, Srinivas M.
    Maheshwari, Akhil
    PEDIATRIC RESEARCH, 2016, 79 (06) : 951 - 961
  • [4] Smad7 interrupts TGF-β signaling in intestinal macrophages and promotes inflammatory activation of these cells during necrotizing enterocolitis
    Krishnan MohanKumar
    Kopperuncholan Namachivayam
    Kalyan C. Chapalamadugu
    Steven A. Garzon
    Muralidhar H. Premkumar
    Srinivas M. Tipparaju
    Akhil Maheshwari
    Pediatric Research, 2016, 79 : 951 - 961
  • [5] Levels of Smad7 regulate Smad and mitogen activated kinases (MAPKs) signaling and controls erythroid and megakaryocytic differentiation of erythroleukemia cells
    Akel, Salem
    Bertolette, Daniel
    Petrow-Sadowski, Cari
    Ruscetti, Francis W.
    PLATELETS, 2007, 18 (08) : 566 - 578
  • [6] Smad7 overexpression in hepatocellular carcinoma:: a mechanism that inactivates TGF-β signaling, thereby potentially contributing to carcinogenesis.
    Wiercinska, E
    Bauche, B
    Tannapfel, A
    Gressner, A
    Dooley, S
    HEPATOLOGY, 2002, 36 (04) : 244A - 244A
  • [7] TGF-β induced miR-132 enhances the activation of TGF-β signaling through inhibiting SMAD7 expression in glioma cells
    Wang, Zhao-hui
    Zhang, Qi-shun
    Duan, Yan-li
    Zhang, Jian-lei
    Li, Guo-fei
    Zheng, Dong-lin
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 463 (03) : 187 - 192
  • [8] TGF-β signaling is activated in patients with chronic HBV infection and repressed by SMAD7 overexpression after successful antiviral treatment
    Nikoletta Argentou
    Georgios Germanidis
    Prodromos Hytiroglou
    Eirini Apostolou
    Themistoklis Vassiliadis
    Kalliopi Patsiaoura
    Paschalis Sideras
    Anastasios E. Germenis
    Matthaios Speletas
    Inflammation Research, 2016, 65 : 355 - 365
  • [9] TGF-β signaling is activated in patients with chronic HBV infection and repressed by SMAD7 overexpression after successful antiviral treatment
    Argentou, Nikoletta
    Germanidis, Georgios
    Hytiroglou, Prodromos
    Apostolou, Eirini
    Vassiliadis, Themistoklis
    Patsiaoura, Kalliopi
    Sideras, Paschalis
    Germenis, Anastasios E.
    Speletas, Matthaios
    INFLAMMATION RESEARCH, 2016, 65 (05) : 355 - 365
  • [10] Smad7 and protein phosphatase 1α are critical determinants in the duration of TGF-β/ALKI signaling in endothelial cells
    Valdimarsdottir, Gudrun
    Goumans, Marie-Jose
    Itoh, Fumiko
    Itoh, Susumu
    Heldin, Carl-Henrik
    ten Dijke, Peter
    BMC CELL BIOLOGY, 2006, 7 (1)
1234