CuII-Catalyzed Coupling with Two Ynone Units by Selective Triple and Sigma C-C and C-H Bond Cleavages

被引：13

作者：

Nan, Jiang ^{[1
]}

Zhang, Jiawen ^{[1
]}

Hu, Yan ^{[1
]}

Wang, Chao ^{[1
]}

Wang, Tingting ^{[1
]}

Wang, Weitao ^{[1
]}

Ma, Yangmin ^{[1
]}

Szostak, Michal ^{[1
,2
]}

机构：

[1] Shaanxi Univ Sci & Technol, Coll Chem & Chem Engn, Shaanxi Key Lab Chem Addit Ind, Xian 710021, Peoples R China

[2] Rutgers State Univ, Dept Chem, Newark, NJ 07102 USA

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 05期

基金：

中国博士后科学基金;

关键词：

D O I：

10.1021/acs.orglett.1c00371

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report a new copper-catalyzed [2 + 2 + 1] annulation process through the selective cleavage of sigma and triple C-C and C-H bonds using two ynone units. This new methodology involves breaking multiple chemical bonds in a single operation, including C C, C-C, C-H, and N-O. These high-value adducts lead to a diverse collection of synthetically challenging trisubstituted indolizines by the simultaneous engagement of different bond-breaking events and show excellent fluorescence in green aqueous solutions.

引用

页码：1928 / 1933

页数：6

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