Comparison of Intralesional Hyaluronic Acid vs. Verapamil for the Treatment of Acute Phase Peyronie's Disease: A Prospective, Open-Label Non-Randomized Clinical Study

被引:18
|
作者
Cocci, Andrea [1 ,2 ]
Di Maida, Fabrizio [1 ]
Cito, Gianmartin [1 ]
Verrienti, Pierangelo [1 ]
Laruccia, Nicola [1 ]
Campi, Riccardo [1 ]
Mari, Andrea [1 ]
Di Mauro, Marina [3 ]
Falcone, Marco [4 ]
Cacciamani, Giovanni E. [5 ]
Garaffa, Giulio [6 ]
Minervini, Andrea [1 ]
Russo, Giorgio Ivan [3 ]
机构
[1] Univ Florence, Careggi Hosp, Dept Urol, Florence, Italy
[2] Villa Donatello Clin, Urol Sect, Sesto Fiorentino, Italy
[3] Univ Catania, Dept Urol, Vittorio Emanuele II, Catania, Italy
[4] Univ Turin, Dept Urol, Turin, Italy
[5] Univ Verona, Dept Urol, Verona, Italy
[6] Univ Coll London Hosp, Inst Urol, London, England
来源
WORLD JOURNAL OF MENS HEALTH | 2021年 / 39卷 / 02期
关键词
Hyaluronic acid; Penile curvature; Penile induration; Peyronie disease; Verapamil;
D O I
10.5534/wjmh.190108
中图分类号
R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
摘要
Purpose: To compare the efficacy and safety of intralesional hyaluronic acid (HA) as compared with verapamil injection in patients with Peyronie's disease (PD). Materials and Methods: Between January 2015 and December 2018, men in PD acute phase were prospectively recruited. This open-label, prospective study included 2 different protocols. Group A: 8-week cycle of weekly intraplaque injections with HA; Group B: 8-week cycle of weekly intraplaque injections with verapamil. Penile curvature, plaque size, International Index of Erectile Function (IIEF)-15 score and visual analogue scale (VAS) were assessed at baseline and after 3 months. Results: Two-hundred forty-four patients were enrolled. Of these, 125 received intralesional HA (Group A), 119 received intralesional verapamil (Group B). At enrollment, median age was 56.0 years (interquartile range [IQR]=47.0-63.0 years), median curvature 35.0 degrees (IQR=25.0 degrees-45.0 degrees), median IIEF-15 score 19.0 (IQR=16.0-23.0), median VAS 4.0 (IQR=4.0-5.0). Median difference for IIEF-15 was 1.0 (95% confidence interval [CI]=1.12-1.94) in Group A and 0.0 (95% CI=-0.04-0.14) in Group B ( p<0.05) and median difference for VAS score was -4.0 (95% CI=-4.11--3.65) in Group A and -1.0 (95% CI=-0.50-2.01) in Group B (p<0.05). Plaque size decreased by -1.50 mm (IQR=1.60-2.10 mm) in Group A and -1.20 in Group B (p=0.10), while penile curvature decreased by -9.50 degrees (IQR=4.50 degrees-13.00 degrees) in group A and -4.50 (IQR=2.50-7.50) in Group B (p<0.01). Conclusions: Intralesional HA injections could represent a reliable treatment option for the conservative management of patients with acute phase of PD.
引用
收藏
页码:352 / 357
页数:6
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