Direct coupling of sp3 carbon of alkanes with α,β-unsaturated carbonyl compounds using a copper/hydroperoxide system

被引：29
|
作者：
Lan, Yun [1 ]
Yang, Chao [1 ]
Xu, Yun-He [1 ]
Loh, Teck-Peng [1 ,2 ]
机构：
[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
[2] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637616, Singapore
来源：
ORGANIC CHEMISTRY FRONTIERS | 2017年 / 4卷 / 07期
基金：
中国国家自然科学基金;
关键词：
C-H BONDS; CYCLIC ETHERS; C(SP(3))-H ACTIVATION; HETEROCYCLE SYNTHESIS; OXIDATIVE ACTIVATION; UNACTIVATED ALKANES; ORGANIC-MOLECULES; RADICAL REACTIONS; C(SP(2))-H BONDS; FUNCTIONALIZATION;
D O I：
10.1039/c7qo00149e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new methodology for the monovalent copper-initiated direct coupling of alkanes and hydroperoxides with unsaturated carbonyl compounds is developed. In this work, alpha, beta-unsaturated carbonyl compounds underwent alkylation and peroxidation to give synthetically useful a-peroxy ketones with wide functional group tolerance. The resulting alpha-peroxy ketones could be easily transformed into very useful a-hydroxy ketones.
引用
收藏
页码：1411 / 1415
页数：5
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