Direct coupling of sp3 carbon of alkanes with α,β-unsaturated carbonyl compounds using a copper/hydroperoxide system

被引：29

作者：

Lan, Yun ^{[1
]}

Yang, Chao ^{[1
]}

Xu, Yun-He ^{[1
]}

Loh, Teck-Peng ^{[1
,2
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

[2] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637616, Singapore

来源：

ORGANIC CHEMISTRY FRONTIERS | 2017年 / 4卷 / 07期

基金：

中国国家自然科学基金;

关键词：

C-H BONDS; CYCLIC ETHERS; C(SP(3))-H ACTIVATION; HETEROCYCLE SYNTHESIS; OXIDATIVE ACTIVATION; UNACTIVATED ALKANES; ORGANIC-MOLECULES; RADICAL REACTIONS; C(SP(2))-H BONDS; FUNCTIONALIZATION;

D O I：

10.1039/c7qo00149e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new methodology for the monovalent copper-initiated direct coupling of alkanes and hydroperoxides with unsaturated carbonyl compounds is developed. In this work, alpha, beta-unsaturated carbonyl compounds underwent alkylation and peroxidation to give synthetically useful a-peroxy ketones with wide functional group tolerance. The resulting alpha-peroxy ketones could be easily transformed into very useful a-hydroxy ketones.

引用

页码：1411 / 1415

页数：5

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