An efficient synthesis of sulfonated quinoline diones by copper catalyzed sulfonylation of activated alkenes with sulfonylhydrazides

被引：40
|
作者：
Wang, Shucheng [1 ]
Huang, Xuhu [1 ]
Wang, Qi [1 ]
Ge, Zemei [1 ]
Wang, Xin [1 ]
Li, Runtao [1 ]
机构：
[1] Peking Univ, State Key Lab Natl & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
来源：
RSC ADVANCES | 2016年 / 6卷 / 14期
基金：
中国国家自然科学基金;
关键词：
DISCOVERY; OXINDOLES; FUNCTIONALIZATION; CASCADE; ARYLSULFONYLATION; DERIVATIVES; CYCLIZATION; NITRILES; IODIDE;
D O I：
10.1039/c5ra27878c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel and highly efficient cascade synthesis of sulfonated quinoline dione derivatives from N-(2-cyanoaryl) methylacrylamides and sulfonylhydrazides in good yields is described. The reaction proceeds through radical addition, cyclization, and imine hydrolysis, in which one new C-C bond and one C=O bond were formed.
引用
收藏
页码：11754 / 11757
页数：4
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