Direct One-Pot Synthesis of Primary 4-Amino-2,3-diaryl-quinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-azido-3-iodoquinolines with Arylboronic Acids

被引：2

作者：

Mphahlele, Malose Jack ^{[1
]}

Mphahlele, Mamasegare Mabel ^{[1
]}

机构：

[1] Univ S Africa, Dept Chem, Coll Sci Engn & Technol, ZA-0003 Pretoria, South Africa

来源：

MOLECULES | 2011年 / 16卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

2-aryl-4-azido-3-iodoquinolines; Suzuki-Miyaura cross-coupling; symmetrical biaryls; 4-azido-2,3-diarylquinolines; 4-amino-2,3-diarylquinolines; PALLADIUM; DERIVATIVES; MOLECULES; DISCOVERY;

D O I：

10.3390/molecules16118958

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Palladium-catalyzed Suzuki-Miyaura cross-coupling of 2-aryl-4-azido-3-iodoquinolines with arylboronic acids afforded the corresponding primary 4-amino-2,3-diarylquinolines in a single-pot operation along with symmetrical biaryls and traces of the 2,3-diaryl-4-azidoquinolines. A plausible mechanism, which implicates palladium hydride species in the reduction of the incipient 2,3-diaryl-4-azidoquinolines to afford the 4-amino-2,3-diarylquinolines is proposed.

引用

页码：8958 / 8972

页数：15

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