Direct One-Pot Synthesis of Primary 4-Amino-2,3-diaryl-quinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-azido-3-iodoquinolines with Arylboronic Acids

被引：2
|
作者：
Mphahlele, Malose Jack [1 ]
Mphahlele, Mamasegare Mabel [1 ]
机构：
[1] Univ S Africa, Dept Chem, Coll Sci Engn & Technol, ZA-0003 Pretoria, South Africa
来源：
MOLECULES | 2011年 / 16卷 / 11期
基金：
新加坡国家研究基金会;
关键词：
2-aryl-4-azido-3-iodoquinolines; Suzuki-Miyaura cross-coupling; symmetrical biaryls; 4-azido-2,3-diarylquinolines; 4-amino-2,3-diarylquinolines; PALLADIUM; DERIVATIVES; MOLECULES; DISCOVERY;
D O I：
10.3390/molecules16118958
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Palladium-catalyzed Suzuki-Miyaura cross-coupling of 2-aryl-4-azido-3-iodoquinolines with arylboronic acids afforded the corresponding primary 4-amino-2,3-diarylquinolines in a single-pot operation along with symmetrical biaryls and traces of the 2,3-diaryl-4-azidoquinolines. A plausible mechanism, which implicates palladium hydride species in the reduction of the incipient 2,3-diaryl-4-azidoquinolines to afford the 4-amino-2,3-diarylquinolines is proposed.
引用
收藏
页码：8958 / 8972
页数：15
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