Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin

被引：101

作者：

Obermeier, Birgit ^{[1
,2
]}

Lovato, Laura ^{[3
,4
]}

Mentele, Reinhard ^{[2
,5
]}

Brueck, Wolfgang ^{[6
]}

Forne, Ignasi ^{[7
]}

Imhof, Axel ^{[7
]}

Lottspeich, Friedrich ^{[5
]}

Turk, Katherine W. ^{[8
]}

Willis, Simon N. ^{[3
,4
]}

Wekerle, Hartmut ^{[1
]}

Hohlfeld, Reinhard ^{[1
,2
]}

Hafler, David A. ^{[9
]}

O'Connor, Kevin C. ^{[9
]}

Dornmair, Klaus ^{[1
,2
]}

机构：

[1] Max Planck Inst Neurobiol, Dept Neuroimmunol, D-82152 Martinsried, Germany

[2] Univ Munich, Inst Clin Neuroimmunol, D-81377 Munich, Germany

[3] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA

[4] Brigham & Womens Hosp, Dept Neurol, Ctr Neurol Dis, Boston, MA 02115 USA

[5] Max Planck Inst Biochem, Dept Prot Analyt, D-82152 Martinsried, Germany

[6] Univ Med Ctr, Dept Neuropathol, D-37075 Gottingen, Germany

[7] Univ Munich, Lab Prot Analyt, D-80336 Munich, Germany

[8] Tufts Univ, Sch Med, Boston, MA 02115 USA

[9] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2011年 / 233卷 / 1-2期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

Multiple sclerosis; B cells; Cerebrospinal fluid; Central nervous system; Oligoclonal bands; EXPANDED PLASMA-CELLS; CEREBROSPINAL-FLUID; BRAIN; ANTIBODIES; EXPANSION; MENINGES; PROTEIN;

D O I：

10.1016/j.jneuroim.2011.01.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the overlap shared between the immunoglobulin (Ig) proteome of the cerebrospinal fluid (CSF) and the B cell Ig-transcriptome of CSF and the central nervous system (CNS) tissue of three patients with multiple sclerosis. We determined the IgG-proteomes of CSF by mass spectrometry, and compared them to the IgG-transcriptomes from CSF and brain lesions, which were analyzed by cDNA cloning. Characteristic peptides that were identified in the CSF-proteome could also be detected in the transcriptomes of both, brain lesions and CSF, providing evidence for a strong overlap of the IgG repertoires in brain lesions and in the CSF. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：245 / 248

页数：4

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