Perspectives on Stem Cell Therapy for Cardiac Regeneration - Advances and Challenges

被引：47

作者：

Choi, Sung Hyun ^{[1
]}

Jung, Seok Yun ^{[2
]}

Kwon, Sang-Mo ^{[2
]}

Baek, Sang Hong ^{[1
]}

机构：

[1] Catholic Univ Korea, Sch Med, Seoul St Marys Hosp, Div Cardiovasc Med,Lab Cardiovasc Regenerat, Seoul, South Korea

[2] Pusan Natl Univ, Sch Med, Dept Physiol, Lab Vasc Med & Stem Cell Biol, Yangsan, South Korea

来源：

CIRCULATION JOURNAL | 2012年 / 76卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

Cardiac regeneration; Heart disease; Stem cell therapy; ENDOTHELIAL PROGENITOR CELLS; ACUTE MYOCARDIAL-INFARCTION; BONE-MARROW; SKELETAL MYOBLASTS; SMOOTH-MUSCLE; HEART; CARDIOMYOCYTES; REPAIR; TRANSPLANTATION; DIFFERENTIATION;

D O I：

10.1253/circj.CJ-11-1479

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ischemic heart disease (IHD) accelerates cardiomyocyte loss, but the developing stem cell research could be useful for regenerating a variety of tissue cells, including cardiomyocytes. Diverse sources of stem cells for IHD have been reported, including embryonic stem cells, induced pluripotent stem cells, skeletal myoblasts, bone marrow-derived stem cells, mesenchymal stem cells, and cardiac stem cells. However, stem cells have unique advantages and disadvantages for cardiac tissue regeneration, which are important considerations in determining the specific cells for improving cell survival and long-term engraftment after transplantation. Additionally, the dosage and administration method of stem cells need to be standardized to increase stability and efficacy for clinical applications. Accordingly, this review presents a summary of the stem cell therapies that have been studied for cardiac regeneration thus far, and discusses the direction of future cardiac regeneration research for stem cells. (Circ J 2012; 76: 1307-1312)

引用

页码：1307 / 1312

页数：6

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