Cross-dehydrogenative alkynylation of sulfonamides and amides with terminal alkynes via Ir(III) catalysis

被引：47

作者：

Wu, Guocai ^{[1
]}

Ouyang, Wensen ^{[1
]}

Chen, Qian ^{[1
]}

Huo, Yanping ^{[1
]}

Li, Xianwei ^{[1
]}

机构：

[1] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou Higher Educ Mega Ctr, 100 Waihuan Xi Rd, Guangzhou 510006, Guangdong, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2019年 / 6卷 / 03期

基金：

中国国家自然科学基金;

关键词：

C-H ALKYNYLATION; LATE-STAGE DIVERSIFICATION; CARBOXYLIC-ACIDS; DECARBOXYLATIVE ALKYNYLATION; PHOTOREDOX CATALYSIS; ARYL SULFONAMIDES; SITE-SELECTIVITY; BOND FORMATION; FUNCTIONALIZATION; ACTIVATION;

D O I：

10.1039/c8qo01105b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Primary sulfonamides are widely used structural skeletons in bioactive molecules, however their direct modification via C-H functionalization remains to be developed. Herein, direct cross-dehydrogenative C-H alkynylations of amides and primary sulfonamides with terminal alkynes is reported. This general process features predictable regioselectivity towards multiple functionalized arenes and the stereoselective generation of tetrasubstituted olefins, which might provide insight into the expedient delivery of related bioactive and material molecules.

引用

页码：284 / 289

页数：6

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