Effective induction of high-titer antibodies by viral vector vaccines

被引：125

作者：

Draper, Simon J. ^{[1
]}

Moore, Anne C. ^{[1
]}

Goodman, Anna L. ^{[1
]}

Long, Carole A. ^{[2
]}

Holder, Anthony A. ^{[3
]}

Gilbert, Sarah C. ^{[1
]}

Hill, Fergal ^{[4
]}

Hill, Adrian V. S. ^{[1
]}

机构：

[1] Univ Oxford, Jenner Inst, Oxford OX3 7DQ, England

[2] NIAID, Lab Malaria & Vector Res, US NIH, Rockville, MD 20852 USA

[3] Natl Inst Med Res, Div Parasitol, London NW7 1AA, England

[4] Imaxio, F-69007 Lyon, France

来源：

NATURE MEDICINE | 2008年 / 14卷 / 08期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1038/nm.1850

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus-poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody responses, and we identify a simple complement-based adjuvant to further enhance immunogenicity. Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro.

引用

页码：819 / 821

页数：3

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