Effective induction of high-titer antibodies by viral vector vaccines

被引：125
|
作者：
Draper, Simon J. [1 ]
Moore, Anne C. [1 ]
Goodman, Anna L. [1 ]
Long, Carole A. [2 ]
Holder, Anthony A. [3 ]
Gilbert, Sarah C. [1 ]
Hill, Fergal [4 ]
Hill, Adrian V. S. [1 ]
机构：
[1] Univ Oxford, Jenner Inst, Oxford OX3 7DQ, England
[2] NIAID, Lab Malaria & Vector Res, US NIH, Rockville, MD 20852 USA
[3] Natl Inst Med Res, Div Parasitol, London NW7 1AA, England
[4] Imaxio, F-69007 Lyon, France
来源：
NATURE MEDICINE | 2008年 / 14卷 / 08期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
D O I：
10.1038/nm.1850
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus-poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody responses, and we identify a simple complement-based adjuvant to further enhance immunogenicity. Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro.
引用
收藏
页码：819 / 821
页数：3
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