Role of proteinuria in the anemia of chronic kidney disease

被引：6
|
作者：
Drueke, Tilman B. [1 ,2 ]
Massy, Ziad A. [1 ,2 ,3 ]
机构：
[1] Paris Ile De France Ouest Univ, Versailles St Quentin En Yvelines Univ, Ctr Rech Epidemiol & Sante Populat CESP, INSERM,UVSQ,U1018, Villejuif, France
[2] Paris Saclay Univ, Villejuif, France
[3] Ambroise Pare Univ Hosp, AP HP, Dept Nephrol, Boulogne, France
来源：
KIDNEY INTERNATIONAL | 2021年 / 100卷 / 06期
关键词：
NEPHROTIC SYNDROME;
D O I：
10.1016/j.kint.2021.09.016
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The most important contributors to the anemia of patients with chronic kidney disease are insufficient erythropoietin production and erythropoietin hyporesponsiveness, decreased red blood cell half-life, iron deficiency, and inflammation. However, in contrast to the role of kidney failure, that of proteinuria and nephrotic syndrome is less clear. Bissinger et al. now provide evidence in mouse models and patients with chronic kidney disease that heavy proteinuria alters erythrocyte metabolism and increases erythrocyte death. Copyright (C) 2021, International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：1160 / 1162
页数：3
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