Tuning drug binding Understanding anticancer drug binding to its target could improve drug discovery and efficacy

被引：3
|
作者：
Slade, Dea [1 ]
Eustermann, Sebastian [2 ]
机构：
[1] Univ Vienna, Vienna Bioctr, Max Perutz Labs, Dr Bohr Gasse 9, A-1030 Vienna, Austria
[2] EMBL, Struct & Computat Biol Unit, Heidelberg, Germany
来源：
SCIENCE | 2020年 / 368卷 / 6486期
基金：
奥地利科学基金会;
关键词：
STRUCTURAL BASIS; PARP; INHIBITORS;
D O I：
10.1126/science.abb1462
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
[No abstract available]
引用
收藏
页码：30 / 31
页数：3
相关论文
共 50 条
  • [41] Usefulness of in vivo Analysis of drug-receptor binding characteristics in drug discovery
    Yamada, Shizuo
    [J]. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, 109 : 13P - 13P
  • [42] Drug-Target Kinetics in Drug Discovery
    Tonge, Peter J.
    [J]. ACS CHEMICAL NEUROSCIENCE, 2018, 9 (01): : 29 - 39
  • [43] Discovery of drug resistance biomarker could improve cancer treatment
    Jones, Sarah
    [J]. PHARMACOGENOMICS, 2013, 14 (02) : 125 - 125
  • [44] Rational understanding of nicotinic receptors drug binding
    Grutter, T
    Le Novère, N
    Changeux, JP
    [J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2004, 4 (06) : 645 - 650
  • [45] Advances in Anticancer Drug Discovery
    Reynisson, Johannes
    [J]. MOLECULES, 2021, 26 (07):
  • [46] Serendipity in anticancer drug discovery
    Hargrave-Thomas, Emily
    Yu, Bo
    Reynisson, Johannes
    [J]. WORLD JOURNAL OF CLINICAL ONCOLOGY, 2012, 3 (01): : 1 - 6
  • [47] How Does a Drug Molecule Find Its Target Binding Site?
    Shan, Yibing
    Kim, Eric T.
    Eastwood, Michael P.
    Dror, Ron O.
    Seeliger, Markus A.
    Shaw, David E.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (24) : 9181 - 9183
  • [48] Anticancer drug discovery and development
    Colotta, Francesco
    [J]. TARGETED THERAPIES IN CANCER: MYTH OR REALITY?, 2008, 610 : 19 - 42
  • [49] Epithelial–mesenchymal transition: a new target in anticancer drug discovery
    Fabrizio Marcucci
    Giorgio Stassi
    Ruggero De Maria
    [J]. Nature Reviews Drug Discovery, 2016, 15 : 311 - 325
  • [50] Novel anticancer drug discovery
    Buolamwini, JK
    [J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 1999, 3 (04) : 500 - 509
12345