NHC-Catalyzed Asymmetric Synthesis of Functionalized Succinimides from Enals and -Ketoamides

被引：30

作者：

Wang, Lei ^{[1
]}

Ni, Qijian ^{[1
]}

Bluemel, Marcus ^{[1
]}

Shu, Tao ^{[1
]}

Raabe, Gerhard ^{[1
]}

Enders, Dieter ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2015年 / 21卷 / 22期

基金：

欧洲研究理事会;

关键词：

asymmetric synthesis; ketoamides; N-heterocyclic carbenes; organocatalysis; succinimides; DIELS-ALDER REACTIONS; HIGHLY ENANTIOSELECTIVE SYNTHESIS; FORMAL 3+2 ANNULATION; ALPHA; BETA-UNSATURATED ALDEHYDES; ENOLATE EQUIVALENTS; CARBENE CATALYSIS; 4+2 CYCLOADDITION; KETENES; ACTIVATION; ESTERS;

D O I：

10.1002/chem.201500661

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The efficient asymmetric synthesis of highly substituted succinimides from ,-unsaturated aldehydes and -ketoamides via NHC-catalyzed [3+2] cycloaddition has been developed. The new scalable protocol significantly expands the utility of NHC catalysis for the synthesis of heterocycles and provides easy access to assemble a wide range of succinimides from simple starting materials.

引用

页码：8033 / 8037

页数：5

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