X-ray-induced radiophotodynamic therapy (RPDT) using lanthanide micelles: Beyond depth limitations

被引：70
|
作者：
Kascakova, Slavka [1 ,2 ]
Giuliani, Alexandre [1 ,3 ]
Lacerda, Sara [4 ]
Pallier, Agnes [4 ]
Mercere, Pascal [1 ]
Toth, Eva [4 ]
Refregiers, Matthieu [1 ]
机构：
[1] Synchrotron SOLEIL, F-91190 Gif Sur Yvette, France
[2] Univ Paris 11, UMR S1193, F-94800 Villejuif, France
[3] INRA, UAR1008, Caracterisat & Elaborat Prod Issus Agr, F-44316 Nantes, France
[4] CNRS, Ctr Biophys Mol, F-45071 Orleans 2, France
来源：
NANO RESEARCH | 2015年 / 8卷 / 07期
关键词：
photodynamic therapy; liponanoparticles; X-ray; deep tumour; photosensitizer; CONTRAST AGENTS; QUANTUM-DOT; LUMINESCENCE; HYPERICIN; COMPLEXES; CELLS; MRI;
D O I：
10.1007/s12274-015-0747-5
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
We report lanthanide-based micelles integrating hypericin (Hyp) for X-ray-triggered photodynamic therapy (PDT). The lanthanide luminescence induced by X-ray irradiation excites the photosensitizer, which leads to the generation of singlet oxygen. This versatile approach can be extended to other photosensitizers or other types of liponanoparticles and can allow for magnetic resonance imaging (MRI) guidance.
引用
收藏
页码：2373 / 2379
页数：7
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