3-(4-Chlorophenyl)quinazolin-4(3H)-one

被引:6
|
作者
Priya, M. Gnana Ruba [2 ]
Srinivasan, T. [1 ]
Girija, K. [3 ]
Chandran, N. Ravi
Velmurugan, D. [1 ]
机构
[1] Univ Madras, Ctr Adv Study Crystallog & Biophys, Madras 600025, Tamil Nadu, India
[2] Sastra Univ, CNK Reddy Coll Pharm, Dept Chem, Thanjavur 613402, India
[3] Mother Theresa Postgrad & Hlth Sci, Pondicherry 605006, India
关键词
D O I
10.1107/S1600536811030935
中图分类号
O7 [晶体学];
学科分类号
0702 ; 070205 ; 0703 ; 080501 ;
摘要
In the title compound, C14H9ClN2O, the quinazoline unit is essentially planar, with a mean deviation from the least-squares plane defined by the ten constituent ring atoms of 0.027 (2) angstrom. The dihedral angle between the mean plane of the quinazoline ring system and the 4-chlorophenyl ring is 44.63 (5)degrees. In the crystal, molecules are linked by intermolecular C-H center dot center dot center dot N and C-H center dot center dot center dot O hydrogen bonds, forming infinite chains of alternating R-2(2)(6) dimers and R-2(2)(14) ring motifs.
引用
收藏
页码:O2310 / U2409
页数:9
相关论文
共 50 条
  • [41] An expedient synthesis of Benzo[h]quinazolin-4(3H)-one:: Structure of samoquasine a revisited
    Chakrabarty, M
    Sarkar, S
    Harigaya, Y
    SYNTHESIS-STUTTGART, 2003, (15): : 2292 - 2294
  • [43] Synthesis and Anticancer Evaluation of Some Novel Quinazolin-4(3H)-one Derivatives
    Gouhar, Rasha S.
    Haneen, David S. A.
    El-Hallouty, Salwa M.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2019, 56 (05) : 1651 - 1660
  • [44] Some new quinazolin-4(3H)-one derivatives, synthesis and antitumor activity
    Alafeefy, Ahmed Mahmoud
    JOURNAL OF SAUDI CHEMICAL SOCIETY, 2011, 15 (04) : 337 - 343
  • [45] Synthesis and evaluation of antiproliferative activity of novel quinazolin-4(3H)-one derivatives
    Ramineni Venkatesh
    Suresh Kasaboina
    Sridhara Janardhan
    Nishant Jain
    Rajashaker Bantu
    Lingaiah Nagarapu
    Medicinal Chemistry Research, 2016, 25 : 2070 - 2081
  • [46] Synthesis and bioactivities evaluation of quinazolin-4(3H)-one derivatives as α-glucosidase inhibitors
    Mahshid Moheb
    Aida Iraji
    Navid Dastyafteh
    Minoo Khalili Ghomi
    Milad Noori
    Somayeh Mojtabavi
    Mohammad Ali Faramarzi
    Fatemeh Rasekh
    Bagher Larijani
    Kamiar Zomorodian
    Seyed Esmaeil Sadat-Ebrahimi
    Mohammad Mahdavi
    BMC Chemistry, 16
  • [47] 3-(2-Aminoethyl)-2-(4-chloroanilino)quinazolin-4(3H)-one methanol 0.75-solvate
    Yang, Xu-Hong
    Chen, Xiao-Bao
    Zhou, Si-Xuan
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O185 - U2898
  • [48] Synthesis and bioactivities evaluation of quinazolin-4(3H)-one derivatives as α-glucosidase inhibitors
    Moheb, Mahshid
    Iraji, Aida
    Dastyafteh, Navid
    Ghomi, Minoo Khalili
    Noori, Milad
    Mojtabavi, Somayeh
    Faramarzi, Mohammad Ali
    Rasekh, Fatemeh
    Larijani, Bagher
    Zomorodian, Kamiar
    Sadat-Ebrahimi, Seyed Esmaeil
    Mahdavi, Mohammad
    BMC CHEMISTRY, 2022, 16 (01)
  • [49] New synthetic route to tetracyclic quinazolin-4(3H)-one ring system
    Mohanta, PK
    Kim, K
    HETEROCYCLES, 2002, 57 (08) : 1471 - 1485
  • [50] Identification of a Naturally Occurring Quinazolin-4(3H)-one Firefly Luciferase Inhibitor
    Somanadhan, Brinda
    Leong, Chungyan
    Whitton, Stephen R.
    Ng, Siewbee
    Buss, Antony D.
    Butler, Mark S.
    JOURNAL OF NATURAL PRODUCTS, 2011, 74 (06): : 1500 - 1502