Metal-free alkylation of quinoxalinones with aryl alkyl ketones

被引：2
|
作者：
Liu, Xinya [1 ]
Guo, Zhuangzhuang [1 ]
Liu, Yanpeng [1 ]
Chen, Xiaoyu [1 ]
Li, Jingya [2 ]
Zou, Dapeng [1 ]
Wu, Yangjie [1 ]
Wu, Yusheng [1 ,3 ]
机构：
[1] Zhengzhou Univ, Coll Chem, Green Catalysis Ctr, Zhengzhou 450052, Peoples R China
[2] TetranovBiopharm LLC, Zhengzhou 450052, Peoples R China
[3] Tetranov Int Inc, 100 Jersey Ave,Suite A340, New Brunswick, NJ 08901 USA
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2022年 / 20卷 / 07期
基金：
中国国家自然科学基金;
关键词：
C-H FUNCTIONALIZATION; HETEROARENES; QUINOXALIN-2(1H)-ONES; DECARBONYLATION; DIARYLMETHANES; METHYLATION; DERIVATIVES; ACTIVATION; DIVERSITY;
D O I：
10.1039/d1ob02260a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first metal-free method for alkylation of quinoxalinones using cheap and stable aryl alkyl ketones as nucleophilic alkylation reagents is reported. This strategy greatly broadens the application channels of aryl alkyl ketones through carbon-carbon bond activation. In addition, the protocol has the advantages of simple operation, broad substrate scope, and good functional group tolerance.
引用
收藏
页码：1391 / 1395
页数：5
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