The design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: A novel series of CRF-1 receptor antagonists

被引：18

作者：

Yoon, Taeyoung ^{[1
]}

De Lombaert, Stephane ^{[1
]}

Brodbeck, Robbin ^{[1
]}

Gulianello, Michael ^{[1
]}

Chandrasekhar, Jayaraman ^{[1
]}

Horvath, Raymond F. ^{[1
]}

Ge, Ping ^{[1
]}

Kershaw, Mark T. ^{[1
]}

Krause, James E. ^{[1
]}

Kehne, John ^{[1
]}

Hoffman, Diane ^{[1
]}

Doller, Dario ^{[1
]}

Hodgetts, Kevin J. ^{[1
]}

机构：

[1] Neurogen Corp, Branford, CT 06405 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 03期

关键词：

CRF-1 receptor antagonist; 1-aryl-4-aminoalkylisoquinoline; depression; anxiety;

D O I：

10.1016/j.bmcl.2007.12.050

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The design, synthesis and structure-activity relationships of a novel series of CRF-1 receptor antagonist, the 1-aryl-4-alkylaminoisoquinolines, is described. The effects of substitution on the aromatic ring, the amino group and the isoquinoline core on CRF-1 receptor binding were investigated. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：891 / 896

页数：6

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