Diverse strategic approaches en route

被引：7
|
作者：
Li, Zexian [1 ]
Zheng, Jianfeng [1 ]
Li, Wei-Dong Z. [1 ]
机构：
[1] Southwest Jiaotong Univ, Sch Life Sci & Engn, Sichuan Engn Res Ctr Biomimet Synth Nat Drugs, Chengdu 610031, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2022年 / 33卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Taxol; Total synthesis; Biomimetic synthesis; Linear strategy; Convergent strategy; RING-CLOSING METATHESIS; TAXANE DITERPENE SYNTHESIS; FORMAL TOTAL-SYNTHESIS; HIGHLY EFFICIENT SYNTHESIS; OXY-COPE REARRANGEMENT; 1ST TOTAL-SYNTHESIS; ABC RING; STEREOSELECTIVE-SYNTHESIS; BIOMIMETIC APPROACH; TAXOL BIOSYNTHESIS;
D O I：
10.1016/j.cclet.2022.04.029
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Taxol is one of the most famous diterpenoid natural products used in clinical cancer therapy. Taxol and its analogues are popular synthetic targets and have attracted worldwide attention over the past decades. Tremendous research efforts have already been made and ten groups have achieved the total synthesis of Taxol since 1994. This mini-review summarized the recent highlights of divergent strategic approaches towards the chemical synthesis of Taxol's carbocyclic framework bearing a bridged eight-membered ring. (c) 2022 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
引用
收藏
页码：4957 / 4968
页数：12
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