Phenolic Enriched Extract of Baccharis trimera Presents Anti-inflammatory and Antioxidant Activities

被引：36
|
作者：
de Oliveira, Cristiane B. [1 ,2 ]
Comunello, Lucimara N. [1 ]
Lunardelli, Adroaldo [2 ]
Amaral, Robson H. [2 ]
Pires, Melissa G. S. [2 ]
da Silva, Gabriela Lucas [2 ]
Manfredini, Vanusa [1 ,3 ]
Vargas, Carmen Regla [1 ,3 ]
Gnoatto, Simone C. B. [1 ]
de Oliveira, Jarbas R. [2 ]
Gosmann, Grace [1 ]
机构：
[1] Univ Fed Rio Grande do Sul, Fac Farm, BR-90610000 Porto Alegre, RS, Brazil
[2] Pontificia Univ Catolica Rio Grande do Sul PUCRS, Lab Biofis Celular & Inflamacao, BR-90619900 Porto Alegre, RS, Brazil
[3] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Serv Genet Med, BR-93050150 Porto Alegre, RS, Brazil
来源：
MOLECULES | 2012年 / 17卷 / 01期
关键词：
anti-inflammatory; antioxidant; Baccharis trimera; phenolic compounds; pleurisy; saponin; TAR; IDENTIFICATION;
D O I：
10.3390/molecules17011113
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Baccharis trimera is a plant popularly used as a tea and to treat gastrointestinal diseases and inflammatory processes as well. The total phenolic content was determined and the antioxidant and anti-inflammatory activities of six extracts (dichloromethane, ethyl acetate, butanol, aqueous, saponin and phenolic) from B. trimera were evaluated. Using carrageenan-induced pleurisy as a model of acute inflammation, the phenolic extract at 15 mg/kg decreased significantly the analyzed parameters when compared to the carrageenan group (p < 0.05), thus showing potential anti-inflammatory activity. The total phenolic content and antioxidant activity were evaluated by the Folin-Ciocalteau and DPPH methods, respectively. Phenolic and ethyl acetate extracts presented higher antioxidant activity (p < 0.05) than ascorbic acid. The phenolic extract also showed the highest antioxidant potential in relation to the other extracts, thus suggesting that the antioxidant and anti-inflammatory activities were due to the presence of phenolic compounds.
引用
收藏
页码：1113 / 1123
页数：11
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