Transcriptional regulation and biological significance of the insulin like growth factor II gene

被引：44
|
作者：
Engström, W
Shokrai, A
Otte, K
Granérus, M
Gessbo, Å
Bierke, P
Madej, A
Sjölund, M
Ward, A
机构：
[1] Swedish Univ Agr Sci, Fac Vet Med, Dept Pathol, S-75007 Uppsala, Sweden
[2] Swedish Univ Agr Sci, Fac Vet Med, Dept Physiol, S-75007 Uppsala, Sweden
[3] Univ Cambridge, Wellcome CRC Inst, Cambridge, England
[4] Univ Bath, Sch Biol & Biochem, Bath BA2 7AY, Avon, England
来源：
CELL PROLIFERATION | 1998年 / 31卷 / 5-6期
基金：
英国惠康基金;
关键词：
D O I：
10.1111/j.1365-2184.1998.tb01196.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The insulin like growth factors I and II are the most ubiquitous in the mammalian embryo. Moreover they play a pivotal role in the development and growth of tumours. The bioavailability of these growth factors is regulated on a transcriptional as well as on a posttranslational level. The expression of non-signalling receptors as well as binding proteins does further tune the local concentration of IGFs. This paper aims at reviewing how the transcription of the IGF genes is regulated. The biological significance of these control mechanisms will be discussed.
引用
收藏
页码：173 / 189
页数：17
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