Immunoglobulin Heavy and Light Chain Isotypes in Multiple Myeloma Patients

被引：0
|
作者：
Ansari, Nadeem A. [1 ]
Owais, M. [2 ]
Usha [3 ]
机构：
[1] AMU, JN Med Coll, Dept Biochem, Aligarh 2, Uttar Pradesh, India
[2] AMU, Interdisciplinary Biotechnol Unit, Aligarh 2, Uttar Pradesh, India
[3] BHU, Div Immunopathol, Varanasi 7, Uttar Pradesh, India
来源：
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2007年 / 8卷 / 04期
关键词：
Plasma cells; multiple myeloma; M-proteins; biclonal gammopathy; biomarkers;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The frequency of expression of immunoglobulin (Ig) light and heavy chain isotypes was analyzed in myeloma proteins (M-proteins) from sera of 40 Indian patients with clinically established multiple myeloma. Patients samples were screened by a combination of electrophoresis, immunoelectrophoresis (IEP) and ELISA techniques in this study. We found that majority of the myeloma proteins (58%) were of the IgG isotype followed by IgA (24%) and biclonal gammopathy associated with IgG and IgA (5%). Both kappa and lambda light chains were associated with the heavy chain isotypes. We recommend the triangular combination for detection of M-proteins and biclonal gammopathy of cancerous plasma cells as biomarkers for diagnosis of myeloma.
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页码：593 / 596
页数：4
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