Immunoglobulin Heavy and Light Chain Isotypes in Multiple Myeloma Patients

被引：0
|
作者：
Ansari, Nadeem A. [1 ]
Owais, M. [2 ]
Usha [3 ]
机构：
[1] AMU, JN Med Coll, Dept Biochem, Aligarh 2, Uttar Pradesh, India
[2] AMU, Interdisciplinary Biotechnol Unit, Aligarh 2, Uttar Pradesh, India
[3] BHU, Div Immunopathol, Varanasi 7, Uttar Pradesh, India
来源：
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2007年 / 8卷 / 04期
关键词：
Plasma cells; multiple myeloma; M-proteins; biclonal gammopathy; biomarkers;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The frequency of expression of immunoglobulin (Ig) light and heavy chain isotypes was analyzed in myeloma proteins (M-proteins) from sera of 40 Indian patients with clinically established multiple myeloma. Patients samples were screened by a combination of electrophoresis, immunoelectrophoresis (IEP) and ELISA techniques in this study. We found that majority of the myeloma proteins (58%) were of the IgG isotype followed by IgA (24%) and biclonal gammopathy associated with IgG and IgA (5%). Both kappa and lambda light chains were associated with the heavy chain isotypes. We recommend the triangular combination for detection of M-proteins and biclonal gammopathy of cancerous plasma cells as biomarkers for diagnosis of myeloma.
引用
收藏
页码：593 / 596
页数：4
相关论文
共 50 条
  • [1] Monitoring IgA Multiple Myeloma: Immunoglobulin Heavy/Light Chain Assays
    Katzmann, Jerry A.
    Willrich, Maria A. V.
    Kohlhagen, Mindy C.
    Kyle, Robert A.
    Murray, David L.
    Snyder, Melissa R.
    Rajkumar, Vincent
    Dispenzieri, Angela
    [J]. CLINICAL CHEMISTRY, 2015, 61 (02) : 360 - 367
  • [2] HEAVY AND LIGHT CHAIN ISOTYPES OF IMMUNOGLOBULIN IN EPIDERMOLYSIS-BULLOSA ACQUISITA
    MOONEY, E
    GAMMON, WR
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1990, 95 (03) : 317 - 319
  • [3] Immunoglobulin heavy/light chain analysis enhances the detection of residual disease and monitoring of multiple myeloma patients
    Batinic, Josip
    Peric, Zinaida
    Segulja, Dragana
    Last, James
    Prijic, Sanja
    Dubravcic, Klara
    Volaric, Lidija
    Sertic, Dubravka
    Radman, Ivo
    Basic-Kinda, Sandra
    Matisic, Danica
    Batinic, Drago
    Labar, Boris
    Nemet, Damir
    [J]. CROATIAN MEDICAL JOURNAL, 2015, 56 (03) : 263 - 271
  • [4] Revisiting the impact of immunoglobulin isotypes in multiple myeloma
    Susan Bal
    Smith Giri
    Kelly N. Godby
    Luciano J. Costa
    [J]. Annals of Hematology, 2022, 101 : 825 - 829
  • [5] Revisiting the impact of immunoglobulin isotypes in multiple myeloma
    Bal, Susan
    Giri, Smith
    Godby, Kelly N.
    Costa, Luciano J.
    [J]. ANNALS OF HEMATOLOGY, 2022, 101 (04) : 825 - 829
  • [6] Revisiting the Impact of Immunoglobulin Isotypes in Multiple Myeloma
    Bal, Susan
    Giri, Smith
    Godby, Kelly N.
    Costa, Luciano J.
    [J]. BLOOD, 2020, 136
  • [7] Immunoglobulin Free Light Chain (FLC) and Heavy Chain/Light Chain (HLC) Assays - Comparison with Electrophoretic Responses in Multiple Myeloma (MM)
    Hari, Parameswaran
    Pasquini, Marcelo C.
    Logan, Brent R.
    Stadtmauer, Edward A.
    Krishnan, Amrita
    Howard, Alan
    Alvi, Sairah
    Harding, Stephen
    Carter, Shelly L.
    Rajkumar, Vincent
    Alyea, Edwin P., III
    Qazilbash, Muzaffar
    Laport, Ginna G.
    Maloney, David G.
    Giralt, Sergio
    Vesole, David H.
    [J]. BLOOD, 2011, 118 (21) : 1241 - 1242
  • [8] Heavy/light chain assay in the monitoring of multiple myeloma
    Ting, Huong Yew
    Sthaneshwar, Pavai
    Bee, Ping Chong
    Shanmugam, Hemalatha
    Lim, Merrell
    [J]. PATHOLOGY, 2019, 51 (05) : 507 - 511
  • [9] Serum immunoglobulin free light chain measurement in intact immunoglobulin multiple myeloma
    Bradwell, AR
    Mead, GP
    Drayson, MT
    Carr-Smith, HD
    [J]. BLOOD, 2002, 100 (11) : 373B - 373B
  • [10] Immunoglobulin light chain variable region genes in multiple myeloma
    Kosmas, C
    Stamatopoulos, K
    [J]. LEUKEMIA, 1999, 13 (05) : 827 - 828
12345