Plasma lipid peroxidation and antioxidant status of Parkinson's disease patients in the Indian population

被引：40

作者：

Sharma, Aabha ^{[1
]}

Kaur, Pushpinder ^{[1
]}

Kumar, Binu ^{[1
]}

Prabhakar, S. ^{[1
]}

Gill, K. D. ^{[1
]}

机构：

[1] Postgrad Inst Med Educ & Res, Dept Biochem, Chandigarh 160012, India

来源：

PARKINSONISM & RELATED DISORDERS | 2008年 / 14卷 / 01期

关键词：

oxidative stress; Parkinson's disease; lipid peroxidation; antioxidant enzymes;

D O I：

10.1016/j.parkreldis.2007.06.009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Present study was to assess lipid peroxidation and antioxidant enzymes in the blood of the Parkinson's disease (PD) patients in the Indian population. it may be useful to develop peripheral markers, for the diagnosis and prognosis of Parkinson's disease during lifetime. Malondialdehyde content was increased in patients with PD (2 fold), with respect to the activity of superoxide-dismutase (P<0.001). The levels of glutathione (p<0.001) and blood thiols were decreased. No changes were observed in gamma-GTP, glutathione peroxidase and glutathione reductase. Increased lipid peroxidation, decreased glutathione levels and increased superoxide dismutase activity in the blood of PD patients indicate oxidative stress. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：52 / 57

页数：6

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