The ER-overload response: Activation of NF-kappa B

被引：285
|
作者：
Pahl, HL [1 ]
Baeuerle, PA [1 ]
机构：
[1] TULARIK INC,S SAN FRANCISCO,CA 94080
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 02期
关键词：
D O I：
10.1016/S0968-0004(96)10073-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Various conditions that perturb the function of the endoplasmic reticulum (ER) were recently shown to activate the transcription factor NF-kappa B, Activation of NF-kappa B is caused by the accumulation of proteins in the ER membrane, a condition we have called ER overload. Both the release of Ca2+ from the ER and the subsequent production of reactive oxygen intermediates are required for ER-overload-mediated NF-kappa B activation. This novel intracellular signal transduction pathway might be important in antiviral defense and play a role in various diseases as well as in B-cell development.
引用
收藏
页码：63 / 67
页数：5
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