3-Butyl-2-morpholino-5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidin-4(3H)-one

被引:0
|
作者
Zeng, Xiao-Hua [1 ]
Wang, Hong-Mei [1 ]
Zheng, Ai-Hua [1 ]
Tian, Jia-Hua [1 ]
He, Ting-Yun [1 ]
机构
[1] Yunyang Med Coll, Dept Med Chem, Shiyan 442000, Peoples R China
关键词
D O I
10.1107/S1600536807057558
中图分类号
O7 [晶体学];
学科分类号
0702 ; 070205 ; 0703 ; 080501 ;
摘要
In the title molecule, C18H25N3O2S, the central thienopyrimidine ring system is essentially planar. The cyclohexene ring, in which the four CH2 groups are disordered in an approximately 1:1 ratio, adopts a half-chair conformation, while the morpholine ring is in a standard chair conformation. The butyl group is disordered in an approximately 2: 1 ratio. In the crystal structure, weak intermolecular C-H center dot center dot center dot O hydrogen-bonding interactions stabilize the crystal structure.
引用
收藏
页码:O4840 / U6279
页数:13
相关论文
共 50 条
  • [21] Synthesis and Crystal Structure of 2-Ethoxy-3-n-butyl-benzofuro [2,3-d]pyrimidin-4(3H)-one
    胡扬根
    丁明武
    Chinese Journal of Structural Chemistry, 2008, (01) : 21 - 24
  • [22] Synthesis and crystal structure of 2-ethoxy-3-n-butyl-benzofuro [2,3-d]pyrimidin-4(3H)-one
    Hu Yang-Gen
    Ding Ming-Wu
    CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2008, 27 (01) : 21 - 24
  • [23] Synthesis and Crystal Structure of 2-Ethoxy-3-n-butyl-benzofuro [2,3-d]pyrimidin-4(3H)-one
    胡扬根
    丁明武
    结构化学, 2008, (01) : 21 - 24
  • [24] Mechanism of the antihyperlipaemic activity and pharmacokinetics of 2-chloramethyl-5,6,7,8-tetrahydrobenzo(b)thieno[2,3-d]pyrimidin-4(3H)-one
    Shishoo, CJ
    Gandhi, TR
    Rathod, IS
    Jain, KS
    Goyal, RK
    ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 1997, 47 (10): : 1125 - 1129
  • [25] 7-Benzyl-2-[(cyclopropylmethyl)amino]-3-phenyl-5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4(3H)-one
    Chen, Hong
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O2191 - U1932
  • [26] 7-Benzyl-3-(4-chlorophenyl)-2-isobutylamino-5,6,7,8-tetrahydropyrido[4 ',3 ': 4,5]thieno[2,3-d] pyrimidin-4(3H)-one
    Chen, Hong
    Liao, Quan-Bin
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : O822 - U2851
  • [27] Synthesis and Antitumor Activity of Some Novel 5,6,7,8-Tetrahydrobenzo-thieno[2,3-d]pyrimidin-4(3H)-one Derivatives
    Wang, Hongmei
    Guo, Shubing
    Hu, Yanggen
    Zeng, Xiaohua
    Yang, Guangyi
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2015, 35 (05) : 1075 - 1080
  • [28] Anticancer Activity Evaluation of New Thieno[2,3-d]pyrimidin-4(3H)-ones and Thieno[3,2-d]pyrimidin-4(3H)-one Derivatives
    Shyyka, Olga
    Pokhodylo, Nazariy
    Finiuk, Nataliya
    Matiychuk, Vasyl
    Stoika, Rostyslav
    Obushak, Mykola
    SCIENTIA PHARMACEUTICA, 2018, 86 (03)
  • [29] SYNTHESIS OF 2-MERCAPTOTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONES
    DEVANI, MB
    SHISHOO, CJ
    PATHAK, US
    SHARMA, BG
    GOKHALE, SV
    PADHYA, AC
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1977, 15 (06): : 575 - 577
  • [30] Reactions of 2-(2-propynylsulfanyl)-5,6,7,8-tetrahydrobenzo[b]thieno[2,3-d]pyrimidin-4(3H)-one with arylsulfenyl chlorides
    Vas'kevich, A. I.
    Vas'kevich, R. I.
    Staninets, V. I.
    But, S. A.
    Chernega, A. N.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2007, 43 (10) : 1526 - 1531