Developmental progress of CRISPR/Cas9 and its therapeutic applications for HIV-1 infection

被引：8
|
作者：
Deng, Qiudi [1 ]
Chen, Zisheng [2 ]
Shi, Lei [3 ]
Lin, Huafeng [1 ,3 ]
机构：
[1] Jinan Univ, Coll Life Sci & Technol, Dept Biotechnol, Guangzhou 510632, Guangdong, Peoples R China
[2] Guangzhou Med Univ, Affiliated Hosp 6, Dept Resp Med, Qingyuan, Peoples R China
[3] Jinan Univ, Dept Food Safety & Nutr Res, Guangzhou, Guangdong, Peoples R China
来源：
REVIEWS IN MEDICAL VIROLOGY | 2018年 / 28卷 / 05期
关键词：
CCR5; CRISPR/Cas9; gene editing; HIV-1; infection; RNA-GUIDED ENDONUCLEASE; ZINC-FINGER-NUCLEASES; HUMAN T-CELLS; LATENT HIV-1; CRYSTAL-STRUCTURE; PROVIRAL DNA; VIRAL ESCAPE; CAS SYSTEMS; GENE; GENOME;
D O I：
10.1002/rmv.1998
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The CRISPR/Cas9 system has been developed as a powerful tool for targeted gene editing. As a result of technical enhancements in recent years, this technology has become the method of choice for efficiently modifying targeted HIV-1 genome efficiently as part of HIV therapy. CRISPR can be modified to target specific sequences that Cas9 then cuts. In this article, we outline the development of the CRISPR/Cas9 system. We also show how this technology can be used for the prevention and treatment of HIV-1 infection. Optimistically, this technology promises to make a significant impact on the fight against HIV-1 in the future.
引用
收藏
页数：7
相关论文
共 50 条
  • [41] The CRISPR/Cas9 system and its applications in crop genome editing
    Bao, Aili
    Burritt, David J.
    Chen, Haifeng
    Zhou, Xinan
    Cao, Dong
    Lam-Son Phan Tran
    [J]. CRITICAL REVIEWS IN BIOTECHNOLOGY, 2019, 39 (03) : 321 - 336
  • [42] CRISPR/Cas9 system and its applications in human hematopoietic cells
    Hu, Xiaotang
    [J]. BLOOD CELLS MOLECULES AND DISEASES, 2016, 62 : 6 - 12
  • [43] CRISPR/Cas9 Delivery System Engineering for Genome Editing in Therapeutic Applications
    Cheng, Hao
    Zhang, Feng
    Ding, Yang
    [J]. PHARMACEUTICS, 2021, 13 (10)
  • [44] A CRISPR/Cas9 approach reveals that the polymerase activity of DNA polymerase is dispensable for HIV-1 infection in dividing and nondividing cells
    Goetze, Russell W.
    Kim, Dong-Hyun
    Schinazi, Raymond F.
    Kim, Baek
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (34) : 14016 - 14025
  • [45] Inhibition of HIV-1 Infection by Gene Editing of CCR5 and CXCR4 Using CRISPR/Cas9
    Li, Shasha
    Li, Chen
    Li, Haitang
    Anh Pham
    Rossi, John
    Burnett, John
    [J]. MOLECULAR THERAPY, 2017, 25 (05) : 172 - 172
  • [46] Inhibition of HIV-1 Infection by Gene Editing of CCR5 and CXCR4 Using CRISPR/Cas9
    Li, Shasha
    Holguin, Leo
    Burnett, John
    [J]. MOLECULAR THERAPY, 2018, 26 (05) : 100 - 101
  • [47] CRISPR/Cas9 guided genome and epigenome engineering and its therapeutic applications in immune mediated diseases
    Singh, Desh Deepak
    Hawkins, R. David
    Lahesmaa, Riitta
    Tripathi, Subhash K.
    [J]. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2019, 96 : 32 - 43
  • [48] Advances in therapeutic CRISPR/Cas9 genome editing
    Schwank, G.
    [J]. EUROPEAN JOURNAL OF HUMAN GENETICS, 2019, 27 : 1053 - 1053
  • [49] The chemistry of Cas9 and its CRISPR colleagues
    Janice S. Chen
    Jennifer A. Doudna
    [J]. Nature Reviews Chemistry, 1
  • [50] Advances in therapeutic CRISPR/Cas9 genome editing
    Savic, Natasa
    Schwank, Gerald
    [J]. TRANSLATIONAL RESEARCH, 2016, 168 : 15 - 21
12345