Synthesis and antimicrobial activity of 8-alkylcarbamato-16H-dinaphtho [2,1-d:1′,2′-g] 1,3,2-dioxaphosphocin 8-oxides

被引：0

作者：

Babu, MFS ^{[1
]}

Rao, LN ^{[1
]}

Venugopal, M ^{[1
]}

Raju, CN ^{[1
]}

Reddy, CS ^{[1
]}

机构：

[1] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India

来源：

HETEROATOM CHEMISTRY | 2001年 / 12卷 / 01期

关键词：

Addition reactions - Alcohols - Antibodies - Biochemistry - Chlorine compounds - Infrared spectroscopy - Mass spectrometry - Molecular structure - Nuclear magnetic resonance spectroscopy - Synthesis (chemical);

D O I：

10.1002/1098-1071(2001)12:1<16::AID-HC4>3.0.CO;2-B

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new family of phosphorus heterocycles, namely 8-alkylcarbamato-16H-dinaphtho-[2,1-d:1',2'-g] 1,3,2-dioxaphosphocin 8-oxides (4a-j) has been obtained by reaction of bis(2-hydroxy-1-naphthyl)methane (3) with a series of dichlorophosphosphinyl carbamates (2a-j) in dry toluene in the presence of triethylamine at 40-45 degreesC. The intermediates 2a-j were obtained by the addition of alcohols/thiol to isocyanatophosphonic dichloride (1) at - 10 degreesC in dry toluene. The structures of rte title compounds were confirmed by the elemental analyses, IR, H-1, C-13, and P-31 NMR spectra. The FAB mass spectrum of one member of the family is discussed. These compounds were found to possess good antimicrobial activity. (C) 2001 John Wiley & Sons, Inc.

引用

页码：16 / 20

页数：5

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