Variation and importance of aspirin resistance in patients with known cardiovascular disease

被引:39
|
作者
Poulsen, Tina Svenstrup
Kristensen, Soren Risom
Korsholm, Lars
Haghfelt, Torben
Jorgensen, Bo
Licht, Peter Bjorn
Mickley, Hans
机构
[1] Odense Univ Hosp, Dept Cardiol, DK-5000 Odense C, Denmark
[2] Odense Univ Hosp, Dept KKA, Clin Chem, DK-5000 Odense, Denmark
[3] Univ So Denmark, Dept Stat, Odense, Denmark
[4] Odense Univ Hosp, Dept Nucl Med, DK-5000 Odense, Denmark
关键词
aspirin; platelets; aspirin resistance;
D O I
10.1016/j.thromres.2006.10.022
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aim: To investigate whether aspirin resistance is a persistent condition, and to evaluate if aspirin resistance affects one-year clinical outcome. Methods and results: Previously we studied 298 patients admitted to hospital with symptoms suggestive of an acute myocardial infarction (MI) despite treatment with aspirin, and 70 patients (23.5%) were aspirin resistant. In the present study, platelet function was reassessed by use of a Platelet Function Analyzer-100 one year later. A total of 187 patients were re-examined, and 17 (9.1%) demonstrated aspirin resistance. Of these 17 patients, 12 also exhibited aspirin resistance at baseline resulting in a 6% (12/ 187) prevalence of persistent aspirin resistance. A total of 34 patients had changed from aspirin resistant at baseline to aspirin sensitive at follow-up. We found a significant decrease in the prevalence of aspirin resistance from baseline (43%) to follow-up (11%) in patients with MI at baseline (p=0.0018). Furthermore, a significant decrease was found for patients without MI at baseline (20% to 9%, p=0.0009). During follow-up, 17% (12/70) of the patients with aspirin resistance at baseline suffered death, MI or stroke compared to 16% (37/227) of aspirin sensitive patients (p=0.868). Conclusion: The prevalence of aspirin resistance varies with the clinical status of the patients, and indeed an acute MI is associated with temporary aspirin resistance. We also found that 6% of patients demonstrate persistent aspirin resistance. The presence of aspirin resistance did not affect one-year clinical outcome. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:477 / 484
页数:8
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