Biosynthesis of Resorcylic Acid Lactone (5S)-5-Hydroxylasiodiplodin in Lasiodiplodia theobromae

被引：7
|
作者：
Kashima, Takasumi [1 ]
Takahashi, Kosaku [1 ]
Matsuura, Hideyuki [1 ]
Nabeta, Kensuke [1 ]
机构：
[1] Hokkaido Univ, Res Fac Agr, Div Appl Biosci, Sapporo, Hokkaido 0608589, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2009年 / 73卷 / 11期
关键词：
lasiodiplodin; biosynthesis; resorcylic acid lactone; Lasiodiplodia theobromae; METABOLITES; RADICICOL;
D O I：
10.1271/bbb.90417
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
An administration study of 2 H-labeled precursors showed that the 9-hydroxydecanoyl unit, the acyl intermediate of lasiodiplodin (1), was also the intermediate of (5S)-5-hydroxylasiodiplodin (2) in Lasiodiplodia theobromae. The incorporation of [O-methyl-H-2(3)]-lasio-diplodin (6) into 2 indicated that hydroxylation at C-5 occurred after cyclization.
引用
收藏
页码：2522 / 2524
页数：3
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