Biosynthesis of Resorcylic Acid Lactone (5S)-5-Hydroxylasiodiplodin in Lasiodiplodia theobromae

被引:7
|
作者
Kashima, Takasumi [1 ]
Takahashi, Kosaku [1 ]
Matsuura, Hideyuki [1 ]
Nabeta, Kensuke [1 ]
机构
[1] Hokkaido Univ, Res Fac Agr, Div Appl Biosci, Sapporo, Hokkaido 0608589, Japan
关键词
lasiodiplodin; biosynthesis; resorcylic acid lactone; Lasiodiplodia theobromae; METABOLITES; RADICICOL;
D O I
10.1271/bbb.90417
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
An administration study of 2 H-labeled precursors showed that the 9-hydroxydecanoyl unit, the acyl intermediate of lasiodiplodin (1), was also the intermediate of (5S)-5-hydroxylasiodiplodin (2) in Lasiodiplodia theobromae. The incorporation of [O-methyl-H-2(3)]-lasio-diplodin (6) into 2 indicated that hydroxylation at C-5 occurred after cyclization.
引用
收藏
页码:2522 / 2524
页数:3
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