Background In our opinion, quantitative methods of assessing the wealthy level of population cannot determine the quality of life of people; different modes to measure happiness and wellbeing show results that are not the same with those of the quantitative assessment. In this way, differences about life conditions in macro-regions, including several countries of similar economic development and traditions are important; another important aspect is the regional differentiation of the standard of living within the state, including the processes of urbanization. Complete measuring well-being and quality of life can be represented by taking in consideration the peculiarities of a person's perception of their situation; moreover, is necessary to take into account the conditions created by public environment and infrastructure. Method In the article, based on an analysis of various approaches to measuring social welfare, we suggest a methodology that allows us to appreciate the well-being and quality of life of people. For this reason, we are considering the possibility to make a comparative assessment of the well-being of macro-regions and micro-regions, with a new criterion, which reflected comfort and life satisfaction. Findings Looking at studies of various approaches to assessing of standard's life, it is revealed that financial performance does not fully and not always correctly reflect the real perception of their well-being by people. The inaccurate reflection of this information may distort many decisions and recommend measures about the government regulation; an examination of migration movements can also provide an opportunity to better assess the perception of the level of well-being and potential opportunities. Improvements Representatives of different regions base the consideration of criterion in assessing the quality of life on the study on the contribution of the level of comfort to the perception of well-being, so the formation of a system of indicators of comfort may assess level of well-being and its impact on the quality of life.