The effect of propranolol on cognitive flexibility and memory in acute cocaine withdrawal

被引：20
|
作者：
Kelley, Brendan J. [5 ]
Yeager, Kenneth R. [6 ]
Pepper, Tom H. [7 ]
Bornstein, Robert A. [6 ]
Beversdorf, David Q. [1 ,2 ,3 ,4 ,7 ]
机构：
[1] Univ Missouri, Dept Radiol, Columbia, MO 65212 USA
[2] Univ Missouri, Dept Neurol, Columbia, MO 65212 USA
[3] Univ Missouri, Dept Psychol, Columbia, MO 65212 USA
[4] Univ Missouri, Thompson Ctr, Columbia, MO 65212 USA
[5] Mayo Clin, Dept Neurol, Rochester, MN USA
[6] Ohio State Univ, Dept Psychiat, Columbus, OH 43210 USA
[7] Ohio State Univ, Dept Neurol, Columbus, OH 43210 USA
来源：
NEUROCASE | 2007年 / 13卷 / 5-6期
关键词：
cocaine; propranolol; noradrenergic; problem solving; cognitive flexibility; semantic memory;
D O I：
10.1080/13554790701846148
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Upregulated noradrenergic activity occurs early in cocaine withdrawal. Our previous work revealed impaired cognitive flexibility in acute cocaine withdrawal, a cognitive domain that appears to be modulated by noradrenergic activity. Therefore, we wished to determine the effect of beta-adrenergic antagonists on cognitive performance in acute cocaine withdrawal. Eleven subjects acutely withdrawing from cocaine were tested in this pilot study on tasks of cognitive flexibility as well as word fluency, attention, verbal memory, and spatial memory, off and on propranolol in a double-blinded manner. Propranolol significantly benefited certain aspects of cognitive flexibility in acute cocaine withdrawal, and improved some measures of verbal fluency and verbal recall. Cocaine withdrawal treatment is characterized by high failure rates. Further research is needed to determine the role this finding of a reversible cognitive impairment in cocaine withdrawal has in treatment.
引用
收藏
页码：320 / 327
页数：8
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