Determination of anticonvulsant drugs in pharmaceutical preparations by micellar liquid chromatography

被引：9
|
作者：
Cholbi-Cholbi, MF [1 ]
Martínez-Pla, JJ [1 ]
Sagrado, S [1 ]
Villanueva-Camañas, RM [1 ]
Medina-Hernández, MJ [1 ]
机构：
[1] Univ Valencia, Dept Quim Analit, E-46100 Valencia, Spain
来源：
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 2004年 / 27卷 / 01期
关键词：
column liquid chromatography; micellar liquid chromatography; anticonvulsant drugs; pharmaceutical preparations;
D O I：
10.1081/JLC-120027092
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A micellar liquid chromatographic method for quality control of pharmaceutical preparations (capsules, pills, tablets, injections, drops, and suppositories) containing the anticonvulsant drugs acetazolamide, carbamacepine, chlordiazepoxide, diazepam, ethosuximide, phenytoin, phenobarbital, and zopiclone has been developed. This methodology involves the use of micellar solutions of cetyltrimethylammonium bromide (CTAB) as mobile phases and UV detection. The proposed approach is rapid and reproducible. Sample preparation only requires dissolution with micellar solvent and adequate dilution with the mobile phase before injection into the chromatographic system.
引用
收藏
页码：153 / 170
页数：18
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