Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer

被引：400
|
作者：
Wakayama, T
Tabar, V
Rodriguez, I
Perry, ACF
Studer, L
Mombaerts, P
机构：
[1] Rockefeller Univ, New York, NY 10021 USA
[2] Mem Sloan Kettering Canc Ctr, Lab Stem Cell & Tumor Biol, New York, NY 10021 USA
来源：
SCIENCE | 2001年 / 292卷 / 5517期
关键词：
D O I：
10.1126/science.1059399
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Embryonic stem (ES) cells are fully pluripotent in that they can differentiate into all cell types, including gametes. We have derived 35 ES cell lines via nuclear transfer (ntES cell lines) from adult mouse somatic cells of inbred, hybrid, and mutant strains. ntES cells contributed to an extensive variety of cell types, including dopaminergic and serotonergic neurons in vitro and germ cells in vivo. Cloning by transfer of ntES cell nuclei could result in normal development of fertile adults. These studies demonstrate the full pluripotency of ntES cells.
引用
收藏
页码：740 / 743
页数：4
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