Histopathological and immunohistochemical studies of lesions associated with Ebola virus in a naturally infected chimpanzee

被引:29
|
作者
Wyers, M
Formenty, P
Cherel, Y
Guigand, L
Fernandez, B
Boesch, C
Le Guenno, B
机构
[1] Ecole Natl Vet, Lab Histopathol Anim, F-43307 Nantes 03, France
[2] Inst Pasteur, WHO, Collaborating Ctr Arboviruses & Haemorrhag Fevers, Paris, France
[3] WHO, Tal Forest Project, Abidjan, Cote Ivoire
[4] WHO, Ctr Swisse Rech Sci, Abidjan, Cote Ivoire
来源
JOURNAL OF INFECTIOUS DISEASES | 1999年 / 179卷
关键词
D O I
10.1086/514300
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Lesions caused by the Cote d'Ivoire subtype of Ebola virus in a naturally infected young chimpanzee were characterized by histopathological and immunohistochemical methods. The predominant lesions consisted of multifocal necrosis in the liver and diffuse fibrinoid necrosis in the red pulp of the spleen. In these sites, macrophages contained large eosinophilic intracytoplasmic inclusion bodies. Immunohistochemical staining indicated that macrophages were a major site of viral replication. The absence of bronchiolar and pulmonary lesions and the paucity of antigen-containing macrophages in the lung suggested that aerosol transmission by this animal was unlikely. There were necrotic foci and antigen-containing macrophages in intestinal lymph nodes, in association with lesions caused by intestinal parasites, suggesting the possibility of virus entry through the digestive tract.
引用
收藏
页码:S54 / S59
页数:6
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