Understanding the interactive effects of irrigation water quality and fertilization on nitrogen mineralization (N-min) and accurately predicting N-min are of great importance for the secure and efficient utilization of brackish water in arid regions. A pot experiment was conducted to determine the N-min under different drip irrigation water salinities and nitrogen application rates and to modify the nitrogen mineralization potential (N-0) and mineralization rate constants (k) of the first-order kinetic equation of N-min. An in situ field experiment was conducted to validate the modified equation. The results showed that the amounts of N-min for water salinities of 1.27, 3.03, and 4.90 g L-1 were 58.9, 76.1, and 45.4 kg ha(-1), respectively. N-min was stimulated when the soil salinities were lower than 6.6, 6.1 and 3.9 g kg(-1) for nitrogen application rates of 255, 315 and 375 kg ha(-1), respectively. Nitrogen application significantly reduced N-min. When the nitrogen application rate increased to 375 kg ha(-1), the net N-min rate remained lower, and the effects of salinity on N-min were attenuated. The N-min model with modified N-0 and k values was developed considering the impacts of soil organic nitrogen, nitrogen application rate, and soil salinity. Model testing indicated that the modified model provided an acceptable estimation of N-min under field conditions. It will be helpful for developing rational fertilization strategies of drip irrigation with brackish water in arid regions.