Non-random primary and secondary chromosomal abnormalities in human gastric cancers

被引：0
|
作者：
Yadav, M
Hopwood, VL
Multani, AS
Mansfield, PF
Takahashi, Y
McIntyre, BW
Udagawa, T
Pathak, S
机构：
[1] UNIV TEXAS, MD ANDERSON CANCER CTR, CELLULAR GENET LAB, DEPT CELL BIOL, HOUSTON, TX 77030 USA
[2] UNIV TEXAS, MD ANDERSON CANCER CTR, DEPT SURG ONCOL, HOUSTON, TX 77030 USA
[3] UNIV TEXAS, MD ANDERSON CANCER CTR, DEPT IMMUNOL, HOUSTON, TX 77030 USA
来源：
ANTICANCER RESEARCH | 1996年 / 16卷 / 4A期
关键词：
gastric cancer; cytogenetics; histopathology; karyotype; fluorescence in situ hybridization (FISH);
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
By using Giemsa-banding and fluorescence in situ hybridization techniques, we have been able to identify primary and secondary cytogenetic abnormalities in four gastric tumors at different stages of development. Structural and numerical abnormalities were present in all four gastric tumors in chromosomes 3, 7, 11, and X. Other abnormalities involving chromosomes 1, 5, 6, 8, 13, 15, 17, 18, 19 and 22 were observed, but only in three advanced gastric tumors, suggesting that these were secondary/tertiary genetic defects. Based on these results it was possible for us to decipher primary and secondary genetic abnormalities in these four gastric tumors.
引用
收藏
页码：1787 / 1795
页数：9
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