Linking kinetochore-microtubule binding to the spindle checkpoint

被引：57

作者：

Burke, Daniel J. ^{[1
]}

Stukenberg, P. Todd ^{[1
]}

机构：

[1] Univ Virginia, Med Ctr, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

来源：

DEVELOPMENTAL CELL | 2008年 / 14卷 / 04期

关键词：

D O I：

10.1016/j.devcel.2008.03.015

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The spindle checkpoint blocks cell-cycle progression until chromosomes are properly attached to the mitotic spindle. Popular models propose that checkpoint proteins associate with kinetochores to produce a "wait anaphase" signal that inhibits anaphase. Recent data suggest that a two-state switch results from using the same kinetochore proteins to bind microtubules and checkpoint proteins. At least eight protein kinases are implicated in spindle checkpoint signaling, arguing that a traditional signal transduction cascade is integral to spindle checkpoint signaling.

引用

页码：474 / 479

页数：6

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