Response inhibition or salience detection in the right ventrolateral prefrontal cortex?

被引：11

作者：

Walther, Stephan ^{[1
]}

Friederich, Hans-Christoph ^{[2
]}

Stippich, Christoph ^{[3
,4
]}

Weisbrod, Matthias

Kaiser, Stefan ^{[5
]}

机构：

[1] Univ Heidelberg, Dept Psychiat, Sect Expt Psychopathol & Neurophysiol, Ctr Psychosocial Med, D-69115 Heidelberg, Germany

[2] Univ Heidelberg, Ctr Psychosocial Med, Dept Gen Internal Med & Psychosomat, D-69115 Heidelberg, Germany

[3] Univ Heidelberg, Dept Neuroradiol, D-69115 Heidelberg, Germany

[4] Univ Basel, Dept Neuroradiol, Basel, Switzerland

[5] Psychiat Univ Hosp Zurich, Dept Social & Gen Psychiat, Zurich, Switzerland

来源：

NEUROREPORT | 2011年 / 22卷 / 15期

关键词：

functional MRI; frontal cortex; go/no-go paradigm; preceding context; response inhibition; salience; INFERIOR FRONTAL-CORTEX; EVENT-RELATED FMRI; NO-GO; FUNCTIONAL MRI; NETWORK; TASKS;

D O I：

10.1097/WNR.0b013e32834af670

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study addresses the question of whether frontal activation in response-inhibition tasks is specifically associated with the suppression of a motor response. An alternative model suggests a role in the detection of behaviorally relevant or salient events. For this purpose, we used functional MRI with an auditory go/no-go paradigm. This paradigm allowed the disentangling of inhibition-related from salience-related effects, which were associated with different frontal regions. Importantly, the right ventrolateral prefrontal cortex consistently showed sensitivity for salience but not for inhibition requirements. This reflects a more general salience-detection mechanism, which is not specific for responseinhibition tasks. NeuroReport 22:778-782 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.

引用

页码：778 / 782

页数：5

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