Cytopathic effects of non-syncytium-inducing and syncytium-inducing human immunodeficiency virus type 1 variants on different CD4+T-cell subsets are determined only by coreceptor expression

被引：28
|
作者：
Kwa, D
Vingerhoed, J
Boeser-Nunnink, B
Broersen, S
Schuitemaker, H
机构：
[1] Univ Amsterdam, Acad Med Ctr, CLB, Dept Clin Viroimmunol, NL-1066 CX Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Expt & Clin Immunol Lab, NL-1066 CX Amsterdam, Netherlands
来源：
JOURNAL OF VIROLOGY | 2001年 / 75卷 / 21期
关键词：
D O I：
10.1128/JVI.75.21.10455-10459.2001
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In peripheral blood mononuclear cells, syncytium-inducing (SI) human immunodeficiency virus type 1 (HIV-1) infected and depleted all CD4(+) T cells, including naive T cells. Non-SI HIV-1 infected and depleted only the CCR5-expressing T-cell subset. This may explain the accelerated CD4 cell loss after SI conversion in vivo.
引用
收藏
页码：10455 / 10459
页数：5
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