Tissue-specific Gene Targeting by the Multiprotein Mammalian DREAM Complex

被引：9

作者：

Flowers, Stephen ^{[1
]}

Beck, George R., Jr. ^{[2
]}

Moran, Elizabeth ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, NJMS UH Canc Ctr, Dept Orthopaed, Newark, NJ 07103 USA

[2] Emory Univ, Sch Med, Div Endocrinol Metab & Lipids, Atlanta, GA 30322 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2011年 / 286卷 / 32期

基金：

美国国家卫生研究院;

关键词：

G(2)/M GENES; B-MYB; DIFFERENTIATION; TRANSCRIPTION; PRB; PROTEIN; EXPRESSION; DISTINCT; MECHANISMS; GROWTH;

D O I：

10.1074/jbc.C111.255091

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mammalian DP, RB-like, E2F, and MuvB-like proteins (DREAM) complex, whose key components include p130 and E2F4, plays a fundamental role in repression of cell cycle-specific genes during growth arrest. Mammalian DREAM is well conserved with Drosophila and Caenorhabditis elegans complexes that repress pivotal developmental genes, but the mammalian complex has been thought to exist only in quiescent cells and not to be linked with development. However, new findings here identify tissue-specific promoters repressed by DREAM in proliferating precursors, revealing a new connection between control of growth arrest and terminal differentiation. Mechanistically, tissue-specific promoter occupation by DREAM is dependent on the integrity of a repressor form of the SWI/SNF chromatin-remodeling complex.

引用

页码：27867 / 27871

页数：5

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