The incidence of laryngeal cancer in Iran: A systematic review and meta-analysis

Objectives: The incidence of larynx cancer (LaC) from different areas of Iran were reported. Nevertheless, there is no available systematic reviews in this regard. Therefore, the present systematic review carried out to estimate the incidence rate of LaC among Iranian people. Method: This systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) in October 2017. A search was concluded using Medline/PubMed, Embase, ISI web of knowledge, Scopus, ScienceDirect, and Google scholar for international papers and four national databases (Scientific Information Database, MagIran, IranMedex, and IranDoc) for Persian papers. The incidence rate of LaC was calculated using random effect model. Result: An aggregate of 166 papers were retrieved in the primary search of the databases. Further screening and advanced refinement of the retrieved studies produced 13 studies totally. The age-standardized rate (ASR) of LaC was 2.70, 95% CI (1.86-3.53) and 0.46, 95% CI (0.31-0.61) in males and females, respectively. Conclusion: In comparison to other parts of the world, the incidence of LaC was lower in Iran. Afterwards, further studies are necessary to outline the exact incidence rate and the trend of LaC in Iran.