International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis

被引：220

作者：

Wise, Sarah K. ^{[1
]}

Lin, Sandra Y. ^{[2
]}

Toskala, Elina ^{[3
]}

Orlandi, Richard R. ^{[4
]}

Akdis, Cezmi A. ^{[5
]}

Alt, Jeremiah A. ^{[4
]}

Azar, Antoine ^{[6
]}

Baroody, Fuad M. ^{[7
]}

Bachert, Claus ^{[8
]}

Canonica, G. Walter ^{[9
]}

Chacko, Thomas ^{[10
]}

Cingi, Cemal ^{[11
]}

Ciprandi, Giorgio ^{[12
]}

Corey, Jacquelynne ^{[7
,13
]}

Cox, Linda S. ^{[13
]}

Creticos, Peter Socrates ^{[6
]}

Custovic, Adnan ^{[14
]}

Damask, Cecelia ^{[15
]}

DeConde, Adam ^{[16
]}

DelGaudio, John M. ^{[1
]}

Ebert, Charles S. ^{[17
]}

Eloy, Jean Anderson ^{[18
]}

Flanagan, Carrie E. ^{[1
]}

Fokkens, Wytske J. ^{[19
]}

Franzese, Christine ^{[20
]}

Gosepath, Jan ^{[21
]}

Halderman, Ashleigh ^{[22
]}

Hamilton, Robert G.

Hoffman, Hans Juergen ^{[23
]}

Hohlfeld, Jens M. ^{[24
]}

Houser, Steven M. ^{[25
]}

Hwang, Peter H. ^{[26
]}

Incorvaia, Cristoforo ^{[27
]}

Jarvis, Deborah ^{[28
]}

Khalid, Ayesha N. ^{[29
]}

Kilpelaeinen, Maritta ^{[30
]}

Kingdom, Todd. T. ^{[31
]}

Krouse, Helene ^{[32
]}

Larenas-Linnemann, Desiree ^{[33
]}

Laury, Adrienne M. ^{[34
]}

Lee, Stella E. ^{[35
]}

Levy, Joshua M. ^{[1
]}

Luong, Amber U. ^{[36
]}

Marple, Bradley F. ^{[22
]}

McCoul, Edward D. ^{[37
]}

McMains, K. Christopher ^{[38
]}

Melen, Erik ^{[39
]}

Mims, James W. ^{[40
]}

Moscato, Gianna ^{[41
]}

Mullol, Joaquim ^{[42
]}

机构：

[1] Emory Univ, Otolaryngol, Atlanta, GA 30308 USA

[2] Johns Hopkins Univ, Otolaryngol, Baltimore, MD 21218 USA

[3] Temple Univ, Otolaryngol, Philadelphia, PA 19122 USA

[4] Univ Utah, Otolaryngol, Salt Lake City, UT 84112 USA

[5] Swiss Inst Allergy & Asthma Res, Allergy Asthma, Davos, Switzerland

[6] Johns Hopkins Univ, Allergy Immunol, Baltimore, MD 21218 USA

[7] Univ Chicago, Otolaryngol, Chicago, IL 60637 USA

[8] Univ Ghent, Otolaryngol, Ghent, Belgium

[9] Humanitas Univ, Resp Dis, Rozzano, Italy

[10] Allergy Immunol, Roswell, GA USA

[11] Eskisehir Osmangazi Univ, Otolaryngol, Eskisehir, Turkey

[12] Osped Policlin San Martino, Allergy Immunol, Genoa, Italy

[13] Allergy Immunol, Ft Lauderdale, FL USA

[14] Imperial Coll London, Pediatr Allergy, London, England

[15] Otolaryngol, Lake Mary, FL USA

[16] Univ Calif San Diego, Otolaryngol, La Jolla, CA 92093 USA

[17] Univ N Carolina, Otolaryngol, Chapel Hill, NC USA

[18] Rutgers New Jersey Med Sch, Otolaryngol, Newark, NJ USA

[19] Univ Amsterdam, Otolaryngol, Amsterdam, Netherlands

[20] Univ Missouri, Otolaryngol, Columbia, MO 65211 USA

[21] Helios Kliniken Wiesbaden, Otorhinolaryngol, Wiesbaden, Germany

[22] Univ Texas Southwestern, Otolaryngol, Houston, TX USA

[23] Univ Aarhus, Resp Dis, Aarhus, Denmark

[24] Hannover Med Sch, Airway Res Fraunhofer Inst Toxicol & Expt Med, German Ctr Lung Res, Resp Med, Hannover, Germany

[25] Case Western Reserve Univ, Otolaryngol, Cleveland, OH 44106 USA

[26] Stanford Univ, Otolaryngol, Stanford, CA 94305 USA

[27] ASST Pini CTO Milan, Allergy Immunol, Milan, Italy

[28] Imperial Coll London, Publ Hlth, London, England

[29] Harvard Med Sch, Otolaryngol, Boston, MA USA

[30] Turku Univ Hosp, Pulm Allergy, Turku, Finland

[31] Univ Colorado, Otolaryngol, Boulder, CO 80309 USA

[32] Univ Texas Rio Grande Valley, Nursing, Bronxville, NY USA

[33] Hosp Med Sur, Pediat Allergy, Mexico City, DF, Mexico

[34] San Antonio Mil Med Ctr, Otolaryngol, San Antonio, TX USA

[35] Univ Pittsburgh, Otolaryngol, Pittsburgh, PA 15260 USA

[36] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Otolaryngol, Houston, TX 77030 USA

[37] Ochsner Clin Fdn, Otolaryngol, New Orleans, LA USA

[38] Uniformed Serv Univ Hlth Sci, Otolaryngol, Bethesda, MD 20814 USA

[39] Karolinska Inst, Pediat Allergy, Solna, Sweden

[40] Wake Forest Univ, Otolaryngol, Winston Salem, NC 27109 USA

[41] Univ Pavia, Allergy Immunol, Pavia, Italy

[42] Univ Barcelona, Hosp Clin, IDIBAPS, Otolaryngol, Barcelona, Spain

[43] Natl Jewish Hlth, Allergy Immunol, Denver, CO USA

[44] Loyola Univ, Otolaryngol, New Orleans, LA 70118 USA

[45] Nippon Med Sch, Pediat, Tokyo, Japan

[46] Heidelberg Univ, Ctr Rhinol & Allergol, Med Fac Mannheim, Rhinol Allergy, Wiesbaden, Germany

[47] Boston Univ, Otolaryngol, Boston, MA 02215 USA

[48] Weill Cornell Med Coll, Otolaryngol, New York, NY USA

[49] Reg Univ Hosp Malaga, Allergy, Malaga, Spain

[50] Univ Calgary, Otolaryngol, Calgary, AB, Canada

来源：

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY | 2018年 / 8卷 / 02期

关键词：

allergen extract; allergy; allergen immunotherapy; allergic rhinitis; antihistamine; asthma; atopic dermatitis; avoidance; biologic; cockroach; conjunctivitis; consensus; corticosteroid; cough; cromolyn; decongestant; eosinophilic esophagitis; environment; epicutaneous immunotherapy; epidemiology; evidence-based medicine; food allergy; genetics; house dust mite; IgE; immunoglobulin E; immunotherapy; inhalant allergy; leukotriene; microbiome; occupational rhinitis; omalizumab; pathophysiology; perennial; pet dander; pollen; probiotic; quality of life; rhinitis; rhinosinusitis; risk factor; saline; seasonal; sensitization; sinusitis; sleep; socioeconomic; specific IgE; subcutaneous immunotherapy; sublingual immunotherapy; systematic review; total IgE; transcutaneous immunotherapy; validated survey; QUALITY-OF-LIFE; HOUSE-DUST-MITE; AZELASTINE NASAL SPRAY; PLACEBO-CONTROLLED TRIAL; SKIN-PRICK TEST; RANDOMIZED-DOUBLE-BLIND; SERUM IMMUNOGLOBULIN-E; ENVIRONMENTAL EXPOSURE UNIT; JAPANESE CEDAR POLLINOSIS; OBSTRUCTIVE SLEEP-APNEA;

D O I：

10.1002/alr.22073

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background: Critical examination of the quality and validity of available allergic rhinitis (AR) literature is necessary to improve understanding and to appropriately translate this knowledge to clinical care of the AR patient. To evaluate the existing AR literature, international multidisciplinary experts with an interest in AR have produced the International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR). Methods: Using previously described methodology, specific topics were developed relating to AR. Each topic was assigned a literature review, evidence-based review (EBR), or evidence-based review with recommendations (EBRR) format as dictated by available evidence and purpose within the ICAR:AR document. Following iterative reviews of each topic, the ICAR:AR document was synthesized and reviewed by all authors for consensus. Results: The ICAR:AR document addresses over 100 individual topics related to AR, including diagnosis, pathophysiology, epidemiology, disease burden, risk factors for the development of AR, allergy testing modalities, treatment, and other conditions/comorbidities associated with AR. Conclusion: This critical review of the AR literature has identified several strengths; providers can be confident that treatment decisions are supported by rigorous studies. However, there are also substantial gaps in the AR literature. These knowledge gaps should be viewed as opportunities for improvement, as often the things that we teach and the medicine that we practice are not based on the best quality evidence. This document aims to highlight the strengths and weaknesses of the AR literature to identify areas for future AR research and improved understanding. (C) 2018 ARS-AAOA, LLC.

引用

页码：108 / 352

页数：245

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