Integrins: roles in cancer development and as treatment targets

被引：443
|
作者：
Jin, H
Varner, J
机构：
[1] Univ Calif San Diego, Dept Med, John & Rebecca Moores Comprehens Canc Ctr, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA
来源：
BRITISH JOURNAL OF CANCER | 2004年 / 90卷 / 03期
关键词：
angiogenesis; metastasis; apoptosis; integrin alpha 5 beta 1; integrin alpha v beta 3;
D O I：
10.1038/sj.bjc.6601576
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The integrin family of cell adhesion proteins promotes the attachment and migration of cells on the surrounding extracellular matrix (ECM). Through signals transduced upon integrin ligation by ECM proteins or immunoglobulin superfamily molecules, this family of proteins plays key roles in regulating tumour growth and metastasis as well as tumour angiogenesis. Several integrins play key roles in promoting tumour angiogenesis and tumour metastasis. Antagonists of several integrins (alpha5beta1, alphavbeta3 and alphavbeta5) are now under evaluation in clinical trials to determine their potential as therapeutics for cancer and other diseases.
引用
收藏
页码：561 / 565
页数：5
相关论文
共 50 条
  • [21] Integrins as targets in therapy
    Bosserhoff, Anja-Katrin
    EXPERT OPINION ON THERAPEUTIC PATENTS, 2006, 16 (07) : 963 - 975
  • [22] Integrins as A New Target for Cancer Treatment
    Lasinska, Izabela
    Mackiewicz, Jacek
    ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2019, 19 (05) : 580 - 586
  • [23] Are Integrins Still Practicable Targets for Anti-Cancer Therapy?
    Alday-Parejo, Begona
    Stupp, Roger
    Ruegg, Curzio
    CANCERS, 2019, 11 (07)
  • [24] Novel targets for anticancer treatment development in colorectal cancer
    Macarulla, Teresa
    Javier Ramos, Francisco
    Capdevila, Jaume
    Saura, Cristina
    Tabernero, Josep
    CLINICAL COLORECTAL CANCER, 2006, 6 (04) : 265 - 272
  • [25] Development of Pancreatic Cancer: Targets for Early Detection and Treatment
    Lerch, Markus M.
    Mayerle, Julia
    Mahajan, Ujjwal
    Sendler, Matthias
    Weiss, F. Ulrich
    Aghdassi, Ali
    Moskwa, Patryk
    Simon, Peter
    DIGESTIVE DISEASES, 2016, 34 (05) : 525 - 531
  • [26] Roles for MDC1 in cancer development and treatment
    Ruff, Sophie E.
    Logan, Susan K.
    Garabedian, Michael J.
    Huang, Tony T.
    DNA REPAIR, 2020, 95
  • [27] The complex roles of efferocytosis in cancer development, metastasis, and treatment
    Tajbakhsh, Amir
    hayat, Seyed Mohammad Gheibi
    Movahedpour, Ahmad
    Savardashtaki, Amir
    Loveless, Reid
    Barreto, George E.
    Teng, Yong
    Sahebkar, Amirhossein
    BIOMEDICINE & PHARMACOTHERAPY, 2021, 140
  • [28] Roles of Microbiota in Cancer: From Tumor Development to Treatment
    Bagheri, Zohreh
    Moeinzadeh, Leila
    Razmkhah, Mahboobeh
    JOURNAL OF ONCOLOGY, 2022, 2022
  • [29] The Multifaceted Roles of Myrrha in the Treatment of Breast Cancer: Potential Therapeutic Targets and Promises
    Shams, Anwar
    Alzahrani, Abdullah Ahmed
    Ayash, Taghreed A.
    Tamur, Shadi
    AL-Mourgi, Majed
    INTEGRATIVE CANCER THERAPIES, 2024, 23
  • [30] Integrins and integrin-associated molecules:: Targets for the development of antimetastasic therapies
    Velasco-Velázquez, MA
    Molina-Guarneros, JA
    Mendoza-Patiño, N
    López, JS
    Mandoki, JJ
    REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION, 1999, 51 (03): : 183 - 193
12345