Sleep quality: A common thread linking depression, post-traumatic stress, and post-concussive symptoms to biomarkers of neurodegeneration following traumatic brain injury

被引:10
|
作者
Gottshall, Jackie L. [1 ]
Agyemang, Amma A. [2 ]
O'Neil, Maya [3 ,4 ,5 ]
Wei, Guo [6 ]
Presson, Angela [6 ]
Hewins, Bryson [7 ]
Fisher, Daniel [7 ]
Mithani, Sara [8 ]
Shahim, Pashtun [1 ,9 ]
Pugh, Mary Jo [6 ,10 ]
Wilde, Elisabeth A. [11 ,12 ]
Devoto, Christina [8 ]
Yaffe, Kristine [13 ,14 ,15 ]
Gill, Jessica [8 ]
Kenney, Kimbra [16 ,17 ,18 ]
Werner, J. Kent [1 ,9 ]
机构
[1] Uniformed Serv Univ Hlth Sci, Ctr Neurosci & Regenerat Med CNRM, Bethesda, MD 20814 USA
[2] Virginia Commonwealth Univ, Sch Med, Dept Phys Med & Rehabil, Richmond, VA USA
[3] VA Portland Hlth Care Syst, Ctr Improve Vet Involvement Care CIVIV, Portland, OR USA
[4] Oregon Hlth & Sci Univ, Dept Psychiat, Portland, OR 97201 USA
[5] Oregon Hlth & Sci Univ, Dept Med Informat & Clin Epidemiol, Portland, OR 97201 USA
[6] Univ Utah, Sch Med, Div Epidemiol, Salt Lake City, UT USA
[7] Uniformed Serv Univ Hlth Sci, Sch Med, Bethesda, MD 20814 USA
[8] NINR, NIH, Bethesda, MD 20892 USA
[9] NIH, Rehabil Med Dept, Clin Ctr, Bldg 10, Bethesda, MD 20892 USA
[10] VA Salt Lake City Hlth Care Syst, Informat Decis Enhancement & Analyt Sci Ctr, Salt Lake City, UT USA
[11] Univ Utah, Sch Med, Dept Neurol, Salt Lake City, UT USA
[12] George E Wahlen VA, Dept Neurol, Salt Lake City, UT USA
[13] Univ Calif San Francisco, Dept Psychiat & Behav Sci, San Francisco, CA 94143 USA
[14] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA
[15] Univ Calif San Francisco, Dept Epidemiol, San Francisco, CA 94143 USA
[16] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA
[17] San Francisco Vet Affairs Hlth Care Syst, Dept Psychiat, 4150 Clement St Box 181G, San Francisco, CA USA
[18] Walter Reed Natl Mil Med Ctr, Natl Intrepid Ctr Excellence, Bethesda, MD USA
关键词
Traumatic brain injury; concussion; sleep disturbance; neurodegeneration; depression; posttraumatic stress disorder; NEUROFILAMENT LIGHT; DEMENTIA; VALIDITY; RISK; TAU; DISTURBANCES; ASSOCIATION; PROGRESSION; INDEX; CSF;
D O I
10.1080/02699052.2022.2037711
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Objective Following mild traumatic brain injury (mTBI), many individuals suffer from persistent post-concussive, depressive, post-traumatic stress, and sleep-related symptoms. Findings from self-report scales link these symptoms to biomarkers of neurodegeneration, although the underlying pathophysiology is unclear. Each linked self-report scale includes sleep items, raising the possibility that despite varied symptomology, disordered sleep may underlie these associations. To isolate sleep effects, we examined associations between post-mTBI biomarkers of neurodegeneration and symptom scales according to composite, non-sleep, and sleep components. Methods Plasma biomarkers and self-report scales were obtained from 143 mTBI-positive warfighters. Pearson's correlations and regression models were constructed to estimate associations between total, sleep, and non-sleep scale items with biomarker levels, and with measured sleep quality. Results Symptom severity positively correlated with biomarker levels across scales. Biomarker associations were largely unchanged when sleep items were included, excluded, or considered in isolation. Pittsburgh Sleep Quality Index demonstrated strong correlations with sleep and non-sleep items of all scales. Conclusion The congruency of associations raises the possibility of a common pathophysiological process underlying differing symptomologies. Given its role in neurodegeneration and mood dysregulation, sleep physiology seems a likely candidate. Future longitudinal studies should test this hypothesis, with a focus on identifying novel sleep-related therapeutic targets.
引用
收藏
页码:633 / 643
页数:11
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