MEDI 75-Design and synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamide-derived inhibitors of CC chemokine receptor 2 (CCR2)

被引：0
|
作者：
Xiao, Zili [1 ]
Delucca, George V. [1 ]
Cherney, Robert J. [1 ]
Shi, Qing [1 ]
Mo, Ruowei [1 ]
Santella, Joseph B. [1 ]
Tebben, Andrew J. [2 ]
Cvijic, Mary Ellen [3 ]
Zhao, Qihong [4 ]
Barrish, Joel C. [1 ]
Carter, Percy H. [1 ]
Yang, Michael G. [1 ]
机构：
[1] Bristol Myers Squibb Res & Dev, Discovery Chem, Princeton, NJ 08543 USA
[2] Bristol Myers Squibb Co, Comp Assisted Drug Design, Princeton, NJ 08543 USA
[3] Bristol Myers Squibb Co, Lead Evaluat, Res & Dev, Princeton, NJ 08543 USA
[4] Bristol Myers Squibb Co, Immunol Biol, Res & Dev, Princeton, NJ 08543 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 236卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
75-MEDI
引用
收藏
页数：1
相关论文
共 50 条
  • [21] Discovery of BMS-741672, a potent, selective, and orally bioavailable antagonist of CC Chemokine Receptor 2 (CCR2)
    Carter, Percy H.
    Yang, Michael G.
    Xiao, Zili
    Cherney, Robert J.
    Batt, Douglas G.
    Brown, Gregory D.
    Chen, Jing
    Cvijic, Mary Ellen
    De Lucca, George V.
    Duncia, John V.
    Ford, Gregory
    Gardner, Daniel S.
    Gillooly, Kathleen
    Ko, Soo S.
    Mandlekar, Sandhya
    Marathe, Punit
    McKinnon, Murray
    Mcintyre, Kim
    Murray, Judith
    Pang, Jian
    Reilly, Timothy P.
    Mo, Ruowei
    Rose, Anne
    Salter-Cid, Luisa
    Santella, Joseph B.
    Shen, Ding Ren
    Shi, Qing
    Srivastava, Anurag
    Tebben, Andrew J.
    Xie, Jenny
    Xu, Songmei
    Zhao, Qihong
    Barrish, Joel C.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
  • [22] Signal Relay by CC Chemokine Receptor 2 (CCR2) and Formylpeptide Receptor 2 (Fpr2) in the Recruitment of Monocyte-derived Dendritic Cells in Allergic Airway Inflammation
    Chen, Keqiang
    Liu, Mingyong
    Liu, Ying
    Wang, Chunyan
    Yoshimura, Teizo
    Gong, Wanghua
    Le, Yingying
    Tessarollo, Lino
    Wang, Ji Ming
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (23) : 16262 - 16273
  • [23] The Requirement of CC-Chemokine Receptor-2 (CCR2) Expression by Bone Marrow-Derived Cells (BMCs) for Arteriogenesis is Stimulus Dependent
    Nickerson, Meghan M.
    Song, Ji
    Owens, Gary K.
    Skalak, Thomas C.
    Price, Richard J.
    FASEB JOURNAL, 2008, 22
  • [24] Novel sulfone-containing di- and trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists
    Cherney, Robert J.
    Mo, Ruowei
    Meyer, Dayton T.
    Voss, Matthew E.
    Lo, Yvonne C.
    Yang, Gengjie
    Miller, Persymphonie B.
    Scherle, Peggy A.
    Tebben, Andrew J.
    Carter, Percy H.
    Decicco, Carl P.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (13) : 3418 - 3422
  • [25] CC chemokine receptor 2 (CCR2) expression promotes diffuse large B-Cell lymphoma survival and invasion
    Hu, Quan-Quan
    Wen, Zhao-Feng
    Huang, Qi-Tang
    Li, Qian
    Zhai, Zhi-Min
    Li, Yan-Li
    LABORATORY INVESTIGATION, 2022, 102 (12) : 1377 - 1388
  • [26] Genetic Ablation of CC Family Chemokine Receptor 2 (CCR2) Mitigates Muscle Dysfunction in the Dystrophic (Mdx) Mouse Diaphragm
    Liang, F.
    Danialou, G.
    Maniakas, A.
    Yim, S.
    Bourdon, J.
    Petrof, B. J.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2009, 179
  • [27] Transplantation of monocyte CC-chemokine receptor 2 (CCR2) deficient bone marrow into ApoE3-Leiden mice inhibits atherogenesis
    Guo, J
    Eck, MV
    Twisk, J
    Maeda, N
    Groot, P
    Berkel, TV
    CIRCULATION, 2002, 105 (14) : E105 - E105
  • [28] Enhanced airway Th2 response after allergen challenge in mice deficient in CC chemokine receptor-2 (CCR2)
    Kim, Y
    Sung, SSJ
    Kuziel, WA
    Feldman, S
    Fu, SM
    Rose, CE
    JOURNAL OF IMMUNOLOGY, 2001, 166 (08): : 5183 - 5192
  • [29] MEDI 72-Design, synthesis and structure-activity relationship of novel CCR2 antagonists
    Kothandaraman, Shankaran
    Donnely, Karla L.
    Jiao, Richard X.
    Butora, Gabor
    Pasternak, Alexander
    Morriello, Gregori J.
    Goble, Steve
    Zhou, Changyou
    Yang, Lihu
    Mills, Sander G.
    MacCoss, Malcolm
    Ayala, Julia M.
    Vicario, Pasquale P.
    Cascieri, Margaret A.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, 236
  • [30] A genetic variation in the promoter of the gene encoding chemokine CC motif receptor 2 (CCR2) associates with flow-mediated vasodilation
    Machicao, Fausto
    Rittig, Kilian
    Balletshofer, Bernd
    Staiger, Harald
    Stefan, Norbert
    Fritsche, Andreas
    Haering, Hans-Ulrich
    DIABETES, 2006, 55 : A546 - A547
12345